Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women
Chacko SA, Song Y, Manson JE, Van Horn L, Eaton C, Martin LW, McTiernan A, Curb JD, Wylie-Rosett J, Phillips LS, Plodkowski RA, Liu S
The American journal of clinical nutrition · 103 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK062290)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-05-26 · Am J Clin Nutr · vol. 94 · número 1 · págs. 209–217
- Editorial
- Elsevier BV
- Citado
- 138 citas · más que el 99% de estudios similares · 11.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins · Nutritional Studies and Diet
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, metabolic syndrome, postmenopausal women, cardiometabolic risk factors, adiposity, dyslipidemia, triglycerides, waist circumference, body mass index, insulin resistance, beta-cell function, calcium and vitamin D supplementation, Women's Health Initiative, inverse probability weighting, nested case-control
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, insulin resistance, vitamin d, linear models, risk factors, cross-sectional studies, double-blind method, postmenopause, aged, middle aged, female, cholesterol, hdl, metabolic syndrome
12 autores
- Sara A. Chacko🇺🇸University of California, Los Angeles
- Yiqing Song🇺🇸Harvard University
- JoAnn E. Manson🇺🇸Harvard University
- Linda Van Horn🇺🇸Northwestern University
- Charles B. Eaton🇺🇸Brown University
- Lisa Warsinger Martin🇺🇸George Washington University
- Anne McTiernan🇺🇸Fred Hutch Cancer Center
- J. David Curb🇺🇸University of Hawaiʻi at Mānoa
- Judith Wylie‐Rosett🇺🇸Yeshiva University
- Lawrence S. Phillips🇺🇸Emory University; Atlanta VA Medical Center
- Raymond A Plodkowski🇺🇸United States Department of Veterans Affairs; University of Nevada, Reno
- Simin Liu🇺🇸 · autor de correspondenciaUniversity of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low concentrations of serum 25-hydroxyvitamin D [25(OH)D] may be associated with cardiometabolic disorders; however, little is known about their relation to intermediate metabolic and lipid markers.
Objective
We investigated the relation of serum 25(OH)D concentrations to fasting insulin, glucose, dyslipidemia, adiposity, and prevalent metabolic syndrome.
Design
We conducted this cross-sectional analysis in 292 postmenopausal women aged 50-79 y in the Women's Health Initiative Calcium-Vitamin D (WHI-CaD) trial. Data were collected from 3 nested case-control studies that measured baseline serum 25(OH)D concentrations. Inverse probability weighting was used to approximate parameter estimates for the WHI-CaD population.
Results
In weighted linear regression models adjusted for age, race-ethnicity, month of blood draw, region, case-control status, smoking, alcohol, physical activity, and history of cardiometabolic risk factors, there was an inverse association of serum 25(OH)D with adiposity [body mass index (BMI): β = -1.12 ± 0.30, P = 0.0002; waist circumference: β = -3.57 ± 0.49, P < 0.0001; waist-hip ratio: β = -0.01 ± 0.002, P < 0.0001], triglycerides (β = -0.10 ± 0.02, P < 0.0001), and triglyceride:HDL-cholesterol ratio (β = -0.11 ± 0.03, P = 0.0003). The multivariable-adjusted odds ratio for metabolic syndrome for the highest (≥52 nmol/L) compared with the lowest (<35 nmol/L) tertile of serum 25(OH)D concentrations was 0.28 (95% CI: 0.14, 0.56). Significant associations remained after adjustment for BMI. We observed no significant associations with LDL cholesterol, HDL cholesterol, insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), or homeostatic model assessment of β cell function (HOMA-β).
Conclusion
Higher serum 25(OH)D concentrations may be inversely associated with adiposity, triglycerides, triglyceride:HDL-cholesterol ratio, and metabolic syndrome but are not associated with LDL and HDL cholesterol, insulin, glucose, HOMA-IR, or HOMA-β in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00000611.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.