The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review
Klemens CM, Berman DR, Mozurkewich EL
BJOG : an international journal of obstetrics and gynaecology · 80 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-06-10 · BJOG · vol. 118 · número 8 · págs. 916–925
- Editorial
- Wiley
- Citado
- 126 citas · más que el 89% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Food Allergy and Anaphylaxis Research · Asthma and respiratory diseases
- Palabras clave
- omega-3 polyunsaturated fatty acids, maternal supplementation, pregnancy, lactation, childhood asthma, food allergy, atopy, IL-13, interferon-gamma, inflammatory cytokines, allergy prevention
- MeSH
- humans, asthma, dermatitis, atopic, hypersensitivity, food hypersensitivity, fatty acids, omega-3, interleukin-13, skin tests, perinatal care, odds ratio, breast feeding, pregnancy, infant, newborn, female, randomized controlled trials as topic, interferon-gamma, biomarkers
3 autores
- Chelsea Klemens🇺🇸Michigan State University
- Deborah Rose Berman🇺🇸University of Michigan; Michigan Medicine
- Ellen Mozurkewich🇺🇸 · autor de correspondenciaUniversity of Michigan; Michigan Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Maternal supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) may modulate immune responses and allergy in neonates and children.
Objective
To determine if n-3 PUFA supplementation during pregnancy and lactation reduces risk for childhood allergic disease.
Search strategy
We searched Medline and all evidence-based medicine reviews for randomised controlled trials comparing the effects of n-3 PUFA and placebo supplementation during pregnancy and/or lactation on childhood allergic diseases and inflammatory cytokines.
Selection criteria
We included studies reporting on food allergy, response to the egg skin prick test (SPT), atopy and asthma in infancy and childhood as well as production of interleukin-13 and interferon-gamma, two cytokines involved in the pathogenesis of asthma. For assessment of inclusion, two authors reviewed all abstracts for suitability and independently extracted data.
Data collection and analysis
Two-by-two tables were constructed and odds ratios (OR) were calculated for the outcomes: response to the SPT, food allergy, atopy and asthma in childhood. The assays differed so data on inflammatory markers were reported in narrative form.
Main results
Five randomised controlled trials (n = 949) were included. n-3 PUFA supplementation during pregnancy reduced 12-month prevalence of positive egg SPT (two trials, 12/87 versus 32/100, OR 0.33, 95% CI 0.16, 0.70) and childhood asthma (two trials, 10/303 versus 17/179, OR 0.349, 95% CI 0.154, 0.788) and significantly reduced cord blood interleukin-13 levels. Supplementation during lactation did not prevent asthma, food allergy or atopy.
Conclusion
n-3 PUFA supplementation during pregnancy decreases childhood asthma and response to SPT.
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