A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis
Bjordal JM, Bensadoun RJ, Tunèr J, Frigo L, Gjerde K, Lopes-Martins RA, Lopes-Martins RA
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 159 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-06-09 · Support Care Cancer · vol. 19 · número 8 · págs. 1069–1077
- Editorial
- Springer Science+Business Media
- Citado
- 272 citas · más que el 96% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, head and neck cancer, chemotherapy, radiotherapy, mucositis prevention, mucositis treatment, red and infrared light
- MeSH
- humans, head and neck neoplasms, stomatitis, antineoplastic agents, health status indicators, severity of illness index, confidence intervals, risk, statistics as topic, low-level light therapy
6 autores
- Jan Magnus Bjordal🇳🇴Høgskolen i Bergen
- René‐Jean Bensadoun🇫🇷Centre Hospitalier Universitaire de Poitiers
- Jan Tunér
- Lúcio Frigo🇧🇷Universidade Cruzeiro do Sul
- Kjersti Gjerde🇳🇴University of Bergen
- Rodrigo AB Lopes-Martins🇧🇷Universidade de São Paulo; Universidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of this study is to review the effects of low-level laser therapy (LLLT) in the prevention and treatment of cancer therapy-induced oral mucositis (OM).
Methods
A systematic review and meta-analysis of randomised placebo-controlled trials of LLLT performed during chemotherapy or radiation therapy in head and neck cancer patients.
Results
We found 11 randomised placebo-controlled trials with a total of 415 patients; methodological quality was acceptable at 4.10 (SD ± 0.74) on the 5-point Jadad scale. The relative risk (RR) for developing OM was significantly (p = 0.02) reduced after LLLT compared with placebo LLLT (RR = 2.03 (95% CI, 1.11 to 3.69)). This preventive effect of LLLT improved to RR = 2.72 (95% CI, 1.98 to 3.74) when only trials with adequate doses above 1 J were included. For treatment of OM ulcers, the number of days with OM grade 2 or worse was significantly reduced after LLLT to 4.38 (95% CI, 3.35 to 5.40) days less than placebo LLLT. Oral mucositis severity was also reduced after LLLT with a standardised mean difference of 1.33 (95% CI, 0.68 to 1.98) over placebo LLLT. All studies registered possible side-effects, but they were not significantly different from placebo LLLT.
Conclusions
There is consistent evidence from small high-quality studies that red and infrared LLLT can partly prevent development of cancer therapy-induced OM. LLLT also significantly reduced pain, severity and duration of symptoms in patients with cancer therapy-induced OM.
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