Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review
Rett BS, Whelan J
Nutrition & metabolism · 168 citas
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Cómo se estudió
- Diseño
- Revisión sistemática (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2011-01-01 · Nutr Metab (Lond) · vol. 8 · número 1 · pág. 36
- Editorial
- BioMed Central
- Citado
- 210 citas · más que el 76% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Sphingolipid Metabolism and Signaling
- Palabras clave
- Arachidonic acid, Linoleic acid, Polyunsaturated fatty acid, Essential fatty acid, Phospholipid, Fatty acid, Biochemistry, Food science, CYP2C8, Biology, Chemistry, Endocrinology, Metabolism, Enzyme, CYP2C9
2 autores
- Brian Rett🇺🇸University of Tennessee at Knoxville
- Jay Whelan🇺🇸 · autor de correspondenciaUniversity of Tennessee at Knoxville
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Linoleic acid, with a DRI of 12-17 g/d, is the most highly consumed polyunsaturated fatty acid in the Western diet and is found in virtually all commonly consumed foods. The concern with dietary linoleic acid, being the metabolic precursor of arachidonic acid, is its consumption may enrich tissues with arachidonic acid and contribute to chronic and overproduction of bioactive eicosanoids. However, no systematic review of human trials regarding linoleic acid consumption and subsequent changes in tissue levels of arachidonic acid has been undertaken.
Objective
In this study, we reviewed the human literature that reported changes in dietary linoleic acid and its subsequent impact on changing tissue arachidonic acid in erythrocytes and plasma/serum phospholipids.
Design
We identified, reviewed, and evaluated all peer-reviewed published literature presenting data outlining changes in dietary linoleic acid in adult human clinical trials that reported changes in phospholipid fatty acid composition (specifically arachidonic acid) in plasma/serum and erythrocytes within the parameters of our inclusion/exclusion criteria.
Results
Decreasing dietary linoleic acid by up to 90% was not significantly correlated with changes in arachidonic acid levels in the phospholipid pool of plasma/serum (p = 0.39). Similarly, when dietary linoleic acid levels were increased up to six fold, no significant correlations with arachidonic acid levels were observed (p = 0.72). However, there was a positive relationship between dietary gamma-linolenic acid and dietary arachidonic acid on changes in arachidonic levels in plasma/serum phospholipids.
Conclusions
Our results do not support the concept that modifying current intakes of dietary linoleic acid has an effect on changing levels of arachidonic acid in plasma/serum or erythrocytes in adults consuming Western-type diets.
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