Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study
Aschebrook-Kilfoy B, Cross AJ, Stolzenberg-Solomon RZ, Schatzkin A, Hollenbeck AR, Sinha R, Ward MH
American journal of epidemiology · 38 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-06-17 · Am J Epidemiol · vol. 174 · número 3 · págs. 305–315
- Editorial
- Oxford University Press
- Citado
- 53 citas · más que el 95% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Diet and metabolism studies · Colorectal Cancer Screening and Detection
- Palabras clave
- Nitrite, Nitrate, Pancreatic cancer, Confidence interval, Medicine, Hazard ratio, Cancer, Internal medicine, Food science, Physiology, Gastroenterology, Chemistry, Biology, Ecology
- MeSH
- humans, pancreatic neoplasms, nitrates, nitrites, diet, diet surveys, multivariate analysis, confidence intervals, proportional hazards models, risk factors, sex factors, meat products, aged, middle aged, united states, male, surveys and questionnaires
7 autores
- Brisa Aschebrook-Kilfoy🇺🇸 · autor de correspondenciaNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Amanda Jane Cross🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Rachael Z. Stolzenberg‐Solomon🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Arthur G. Schatzkin🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- A. R. Hollenbeck🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Rashmi R. Sinha🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Mary H. Ward🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nitrate and nitrite are precursors of N-nitroso compounds, which induce tumors of the pancreas in animals. The authors evaluated the relation of dietary nitrate and nitrite to pancreatic cancer risk in the NIH-AARP Diet and Health Study. Nitrate and nitrite intakes were assessed at baseline using a 124-item food frequency questionnaire. During approximately 10 years of follow-up between 1995 and 2006, 1,728 incident pancreatic cancer cases were identified. There was no association between total nitrate or nitrite intake and pancreatic cancer in men or women. However, men in the highest quintile of summed nitrate/nitrite intake from processed meat had a nonsignificantly elevated risk of pancreatic cancer (hazard ratio = 1.18, 95% confidence interval: 0.95, 1.47; P-trend = 0.11). The authors observed a stronger increase in risk among men for nitrate/nitrite intake from processed meat at ages 12-13 years (highest quintile vs. lowest: hazard ratio = 1.32, 95% confidence interval: 0.99, 1.76; P-trend = 0.11), though the relation did not achieve statistical significance. The authors found no associations between adult or adolescent nitrate or nitrite intake from processed meats and pancreatic cancer among women. These results provide modest evidence that processed meat sources of dietary nitrate and nitrite may be associated with pancreatic cancer among men and provide no support for the hypothesis in women.
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