A randomized controlled intervention with fish oil versus sunflower oil from 9 to 18 months of age: exploring changes in growth and skinfold thicknesses
Andersen AD, Michaelsen KF, Hellgren LI, Trolle E, Lauritzen L
Pediatric research · 20 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Strategiske Forskningsråd
Según 1 financiador declarado.
Publicación
- Publicado
- 2011-06-18 · Pediatr Res · vol. 70 · número 4 · págs. 368–374
- Editorial
- Springer Nature
- Citado
- 25 citas · más que el 89% de estudios similares · 2.9× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Infant Nutrition and Health
- Palabras clave
- fish oil, sunflower oil, n-3 long-chain polyunsaturated fatty acids, adipose tissue expansion, skinfold thickness, adipokines, dietary supplementation, omega-6 fatty acids, erythrocyte fatty acids, infant growth
- MeSH
- adipose tissue, erythrocytes, animals, humans, leptin, fatty acids, omega-3, fatty acids, fish oils, plant oils, anthropometry, skinfold thickness, diet, double-blind method, energy intake, dietary supplements, infant, female, male, adiponectin, sunflower oil
5 autores
- Anders Daniel Andersen🇩🇰University of Copenhagen
- Kim F. Michaelsen🇩🇰University of Copenhagen
- Lars Ingvar Hellgren🇩🇰Technical University of Denmark
- Ellen Trolle🇩🇰Technical University of Denmark
- Lotte Lauritzen🇩🇰 · autor de correspondenciaUniversity of Copenhagen
Resumen
El texto original del estudio, en el idioma en que se publicó.
n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), from fish oil (FO), in rodents have been shown to reduce adipogenesis. Evidence of an effect on adipose tissue mass in humans is limited, and no studies have specifically aimed to elucidate this in infancy. To explore whether n-3 LCPUFA intake affects adipose tissue growth, we randomly allocated 154 healthy infants to daily supplementation with FO or sunflower oil (SO) from 9 to 18 mo of age and measured z-score changes in various anthropometric assessments of body size and skinfold thicknesses and plasma adipokine concentrations. Among the 133 completing infants, erythrocyte n-3 PUFA increased more in those receiving FO than in infants receiving SO [12.2 ± 0.7 (mean ± SE) versus 2.0 ± 0.4 fatty acid percentage (FA%), p < 0.001] with a concomitant larger decrease in n-6 PUFA (-8.9 ± 0.7 versus -0.9 ± 0.6 FA%, p < 0.001). We found no association between FO consumption relative to SO consumption and any of the anthropometric measures related to the size of the fat mass, but infants in the FO group had a lower skinfold ratio (triceps/subscapular) at 18 mo than those in SO group (p = 0.02). Our findings do not support the hypothesis that dietary n-3 LCPUFA is important for infant fat mass, but future studies testing this specifically are warranted.
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