Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5
Huong le D, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD
Journal of agricultural and food chemistry · 36 citas
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- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
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- Resultado principal
- Solo mecanismos
Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2011-06-27 · J Agric Food Chem · vol. 59 · número 15 · págs. 8124–8131
- Editorial
- American Chemical Society
- Citado
- 46 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Garlic and Onion Studies · Nitrogen and Sulfur Effects on Brassica
- Palabras clave
- Phenethyl isothiocyanate, MAPK/ERK pathway, Apoptosis, Cruciferous vegetables, p38 mitogen-activated protein kinases, Programmed cell death, Kinase, Cancer research, Carcinogenesis, Isothiocyanate, Chemistry, Cancer cell, Biology, Cancer, Cell biology, Biochemistry
- MeSH
- cell line, tumor, humans, brassicaceae, vegetables, isothiocyanates, plant extracts, anticarcinogenic agents, apoptosis, cell proliferation, uterine cervical neoplasms, female, receptors, tnf-related apoptosis-inducing ligand
10 autores
- Le Diem Huong🇰🇷Jeonbuk National University
- Jung-Hyung Shim🇰🇷Soonchunhyang University
- Kyeong‐Hee Choi🇰🇷Jeonbuk National University
- Ji‐Ae Shin🇰🇷Jeonbuk National University
- Eun‐Sun Choi🇰🇷Jeonbuk National University
- Hyung‐Seop Kim🇰🇷Jeonbuk National University
- Sook-Jeong Lee🇰🇷University of Ulsan
- Sun‐Ju Kim🇰🇷Cheongju University
- Nam‐Pyo Cho🇰🇷Jeonbuk National University
- Sung‐Dae Cho🇰🇷 · autor de correspondenciaJeonbuk National University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cruciferous vegetables have been shown to have the possibility to protect against multistep carcinogenesis. β-Phenylethyl isothiocyanate (PEITC) is one component of these vegetables demonstrated to help fight many types of cancer. The present study examined the apoptotic effects of PEITC and its molecular mechanism in human cervical cancer cell lines (HEp-2 and KB). PEITC induced apoptosis to inhibit cell proliferation. According to the protein chip assay, PEITC increased the expression of the death receptors (DR4 and DR5) and cleaved caspase-3 compared to the DMSO treatment group. PEITC also induced caspase-8 and truncated BID. PEITC down-regulated the phosphorylation of extracellular-related kinase (ERK)1/2, whereas neither phospho-c-Jun NH(2)-terminal kinases (JNK) nor phospho-p38 MAPK was changed. The role of ERK in PEITC-induced apoptosis was also investigated using MEK inhibitor (PD98059). PD98059 increased the expression of DR4 and DR5, activated caspase-3, and cleaved PARP. In addition, PEITC decreased the phosphorylation of MEK. Therefore, the apoptotic mechanism of PEITC in cervical cancer cells involves the induction of DR4 and DR5 through the inactivation of ERK and MEK.
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