Cutaneous vascular and core temperature responses to sustained cold exposure in hypoxia
Simmons GH, Barrett-O'Keefe Z, Minson CT, Halliwill JR
Experimental physiology · 20 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL065305)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-06-25 · Exp Physiol · vol. 96 · número 10 · págs. 1062–1071
- Editorial
- Wiley
- Citado
- 25 citas · más que el 74% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · High Altitude and Hypoxia · Thermal Regulation in Medicine
- Palabras clave
- hypoxia, cold exposure, cutaneous vascular conductance, skin blood flow, core body temperature, yohimbine, adrenergic receptors, propranolol, cold stress, poikilocapnic hypoxia
- MeSH
- skin, humans, propranolol, yohimbine, laser-doppler flowmetry, body temperature, microdialysis, galvanic skin response, oxygen consumption, skin temperature, regional blood flow, vasoconstriction, vasodilation, female, male, cold temperature, skin physiological phenomena, young adult, hypoxia
4 autores
- Grant H. Simmons🇺🇸University of Oregon
- Zachary Barrett‐O’Keefe🇺🇸University of Oregon
- Christopher Todd Minson🇺🇸University of Oregon
- John R. Halliwill🇺🇸University of Oregon
Resumen
El texto original del estudio, en el idioma en que se publicó.
We tested the effect of hypoxia on cutaneous vascular regulation and defense of core temperature during cold exposure. Twelve subjects had two microdialysis fibres placed in the ventral forearm and were immersed to the sternum in a bathtub on parallel study days (normoxia and poikilocapnic hypoxia with an arterial O(2) saturation of 80%). One fibre served as the control (1 mM propranolol) and the other received 5 mM yohimbine (plus 1 mM propranolol) to block adrenergic receptors. Skin blood flow was assessed at each site (laser Doppler flowmetry), divided by mean arterial pressure to calculate cutaneous vascular conductance (CVC), and scaled to baseline. Cold exposure was first induced by a progressive reduction in water temperature from 36 to 23°C over 30 min to assess cutaneous vascular regulation, then by clamping the water temperature at 10°C for 45 min to test defense of core temperature. During normoxia, cold stress reduced CVC in control (-44 ± 4%) and yohimbine sites (-13 ± 7%; both P 0.05). We conclude that hypoxia increases cutaneous (non-noradrenergic) vasoconstriction during prolonged cold exposure, while core cooling rate is not consistently affected.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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