High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes
Manley BJ, Makrides M, Collins CT, McPhee AJ, Gibson RA, Ryan P, Sullivan TR, Davis PG, DINO Steering Committee
Pediatrics · 99 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-06-28 · Pediatrics · vol. 128 · número 1 · págs. e71–e77
- Editorial
- American Academy of Pediatrics
- Citado
- 146 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Neonatal Respiratory Health Research
- Palabras clave
- docosahexaenoic acid, preterm infants, breast milk supplementation, tuna oil, soybean oil, bronchopulmonary dysplasia, atopic diseases, allergic rhinitis, asthma, atopic dermatitis, food allergy, omega-3 fatty acids, birth weight, sex differences
- MeSH
- humans, bronchopulmonary dysplasia, hypersensitivity, docosahexaenoic acids, double-blind method, time factors, dietary supplements, infant, newborn, infant, premature, female, male
8 autores
- Brett James Manley🇦🇺Royal Women's Hospital; The University of Melbourne; Murdoch Children's Research Institute
- Maria Makrides🇦🇺Women's and Children's Hospital; Flinders Medical Centre; Women's & Children's Health Research Institute
- Carmel T Collins🇦🇺Women's and Children's Hospital; Flinders Medical Centre; Women's & Children's Health Research Institute
- Andrew J McPhee🇦🇺Women's and Children's Hospital; Women's and Children's Health Network
- Robert Alan Gibson🇦🇺Women's and Children's Hospital; Flinders Medical Centre; Women's & Children's Health Research Institute
- Philip Ryan
- Thomas Sullivan🇦🇺The University of Adelaide
- Peter Graham Davis🇦🇺 · autor de correspondenciaRoyal Women's Hospital; The University of Melbourne; Murdoch Children's Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Docosahexaenoic acid (DHA) has been associated with downregulation of inflammatory responses.
Objective
To report the effect of DHA supplementation on long-term atopic and respiratory outcomes in preterm infants.
Methods
This study is a multicenter, randomized controlled trial comparing the outcomes for preterm infants <33 weeks' gestation who consumed expressed breast milk from mothers taking either tuna oil (high-DHA diet) or soy oil (standard-DHA) capsules. Data collected included incidence of bronchopulmonary dysplasia (BPD) and parental reporting of atopic conditions over the first 18 months of life.
Results
Six hundred fifty-seven infants were enrolled (322 to high-DHA diet, 335 to standard), and 93.5% completed the 18-month follow-up. There was a reduction in BPD in boys (relative risk [RR]: 0.67 [95% confidence interval (CI): 0.47-0.96]; P=.03) and in all infants with a birth weight of <1250 g (RR: 0.75 [95% CI: 0.57-0.98]; P=.04). There was no effect on duration of respiratory support, admission length, or home oxygen requirement. There was a reduction in reported hay fever in all infants in the high-DHA group at either 12 or 18 months (RR: 0.41 [95% CI: 0.18-0.91]; P=.03) and at either 12 or 18 months in boys (RR: 0.15 [0.03-0.64]; P=.01). There was no effect on asthma, eczema, or food allergy.
Conclusions
DHA supplementation for infants of <33 weeks' gestation reduced the incidence of BPD in boys and in all infants with a birth weight of <1250 g and reduced the incidence of reported hay fever in boys at either 12 or 18 months.
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