Postprandial lipid responses to an alpha-linolenic acid-rich oil, olive oil and butter in women: a randomized crossover trial
Svensson J, Rosenquist A, Ohlsson L
Lipids in health and disease · 10 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Lunds Universitet
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2011-06-28 · Lipids Health Dis · vol. 10 · número 1 · pág. 106
- Editorial
- BioMed Central
- Citado
- 18 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Lipid metabolism and biosynthesis
- Palabras clave
- postprandial lipemia, alpha-linolenic acid, olive oil, butter, dietary fat composition, plasma triglycerides, free fatty acids, oleic acid, palmitic acid, n-6/n-3 ratio, women, premenopausal women, atherogenic risk
- MeSH
- humans, cholesterol, dietary fats, butter, alpha-linolenic acid, linseed oil, fatty acids, fatty acids, monounsaturated, triglycerides, lipoproteins, plant oils, cross-over studies, postprandial period, food, fortified, adult, middle aged, female, male, lipid metabolism, hyperlipidemias, olive oil, rapeseed oil
3 autores
- Julia Svensson🇸🇪Lund University
- Anna Rosenquist🇸🇪Lund University
- Lena Ohlsson🇸🇪 · autor de correspondenciaLund University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Postprandial lipaemia varies with gender and the composition of dietary fat due to the partitioning of fatty acids between beta-oxidation and incorporation into triacylglycerols (TAGs). Increasing evidence highlights the importance of postprandial measurements to evaluate atherogenic risk. Postprandial effects of alpha-linolenic acid (ALA) in women are poorly characterized. We therefore studied the postprandial lipid response of women to an ALA-rich oil in comparison with olive oil and butter, and characterized the fatty acid composition of total lipids, TAGs, and non-esterified fatty acids (NEFAs) in plasma.
Methods
A randomized crossover design (n = 19) was used to compare the postprandial effects of 3 meals containing 35 g fat. Blood samples were collected at regular intervals for 7 h. Statistical analysis was carried out with ANOVA (significant difference = P < 0.05).
Results
No significant difference was seen in incremental area under the curve (iAUC) plasma-TAG between the meals. ALA and oleic acid levels were significantly increased in plasma after ALA-rich oil and olive oil meals, respectively. Palmitic acid was significantly increased in plasma-TAG after the butter meal. The ratios of 18:2 n-6 to18:3 n-3 in plasma-TAGs, three and seven hours after the ALA-rich oil meal, were 1.5 and 2.4, respectively. The corresponding values after the olive oil meal were: 13.8 and 16.9; and after the butter meal: 9.0 and 11.6.
Conclusions
The postprandial p-TAG and NEFA response in healthy pre-menopausal women was not significantly different after the intake of an ALA-rich oil, olive oil and butter. The ALA-rich oil significantly affected different plasma lipid fractions and improved the ratio of n-6 to n-3 fatty acids several hours postprandially.
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