Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial
Mitri J, Dawson-Hughes B, Hu FB, Pittas AG
The American journal of clinical nutrition · 303 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Office of Dietary Supplements
- Gobierno
- U.S. Department of Agriculture
- Universidad u hospital
- Tufts Medical Center
- Organización sin fines de lucro
- Endocrine Fellows Foundation
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- U.S. Department of Agriculture (58‐1950‐4‐401); National Center for Research Resources (RR-025752); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK76092); National Center for Research Resources (UL1RR025752); National Institutes of Health (58-1950-4-401)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2011-06-30 · Am J Clin Nutr · vol. 94 · número 2 · págs. 486–494
- Editorial
- Elsevier BV
- Citado
- 426 citas · más que el 100% de estudios similares · 27.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Pancreatic function and diabetes · Diabetes Treatment and Management
- Palabras clave
- vitamin D supplementation, calcium supplementation, vitamin D3, calcium carbonate, type 2 diabetes prevention, beta-cell function, insulin sensitivity, insulin secretion, glycemic control, HbA1c, glucose homeostasis, high-risk adults
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, calcium, dietary, insulin, blood glucose, vitamin d, risk, follow-up studies, double-blind method, dietary supplements, middle aged, female, male, insulin-secreting cells, insulin secretion
4 autores
- Joanna Mitri🇺🇸Tufts Medical Center
- Bess Dawson‐Hughes🇺🇸Tufts University; Brigham and Women's Hospital; Tufts Medical Center; United States Department of Agriculture; Harvard University
- Frank B. Hu🇺🇸Tufts University; Brigham and Women's Hospital; Tufts Medical Center; United States Department of Agriculture; Harvard University
- Anastassios G. Pittas🇺🇸 · autor de correspondenciaTufts University; Brigham and Women's Hospital; Tufts Medical Center; United States Department of Agriculture; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A suboptimal vitamin D and calcium status has been associated with higher risk of type 2 diabetes in observational studies, but evidence from trials is lacking.
Objective
We determined whether vitamin D supplementation, with or without calcium, improved glucose homeostasis in adults at high risk of diabetes.
Design
Ninety-two adults were randomly assigned in a 2-by-2 factorial-design, double-masked, placebo-controlled trial to receive either cholecalciferol (2000 IU once daily) or calcium carbonate (400 mg twice daily) for 16 wk. The primary outcome was the change in pancreatic β cell function as measured by the disposition index after an intravenous-glucose-tolerance test. Other outcomes were acute insulin response, insulin sensitivity, and measures of glycemia.
Results
Participants had a mean age of 57 y, a body mass index (BMI; in kg/m(2)) of 32, and glycated hemoglobin (Hb A(1c)) of 5.9%. There was no significant vitamin D × calcium interaction on any outcomes. The disposition index increased in the vitamin D group and decreased in the no-vitamin D group (adjusted mean change ± SE: 300 ± 130 compared with -126 ± 127, respectively; P = 0.011), which was explained by an improvement in insulin secretion (62 ± 39 compared with -36 ± 37 mU · L(-1) · min, respectively; P = 0.046). Hb A(1c) increased less, but nonsignificantly, in the vitamin D group than in the no-vitamin D group (0.06 ± 0.03% compared with 0.14 ± 0.03%, respectively; P = 0.081). There was no significant difference in any outcomes with calcium compared with no calcium.
Conclusion
In adults at risk of type 2 diabetes, short-term supplementation with cholecalciferol improved β cell function and had a marginal effect on attenuating the rise in Hb A(1c). This trial was registered at clinicaltrials.gov as NCT00436475.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.