Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: a randomized, controlled clinical trial
Hopkins MH, Owen J, Ahearn T, Fedirko V, Flanders WD, Jones DP, Bostick RM
Cancer prevention research (Philadelphia, Pa.) · 104 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R03CA136113); National Cancer Institute (R01CA104637)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-07-01 · Cancer Prev Res (Phila) · vol. 4 · número 10 · págs. 1645–1654
- Editorial
- American Association for Cancer Research
- Citado
- 138 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Palabras clave
- vitamin D3 supplementation, calcium supplementation, colorectal adenoma, inflammatory markers, C-reactive protein, TNF-α, interleukin-6, IL-1β, interleukin-8, IL-10, nonsteroidal anti-inflammatory drugs, chemoprevention, colorectal neoplasia
- MeSH
- humans, colorectal neoplasms, calcium, vitamin d, inflammation mediators, immunoenzyme techniques, enzyme-linked immunosorbent assay, prognosis, follow-up studies, double-blind method, dietary supplements, adult, aged, middle aged, female, male, biomarkers, tumor
7 autores
- Myfanwy H. Hopkins🇺🇸Emory University; Winship Cancer Institute
- Joy R. Owen🇺🇸Emory University; Winship Cancer Institute
- Thomas U. Ahearn🇺🇸Emory University; Winship Cancer Institute
- Veronika Fedirko🇺🇸Emory University; Winship Cancer Institute
- W. Dana Flanders🇺🇸Emory University; Winship Cancer Institute
- Dean P. Jones🇺🇸Emory University; Winship Cancer Institute
- Roberd M. Bostick🇺🇸 · autor de correspondenciaEmory University; Winship Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D and calcium affect several pathways involved in inflammation, tumor growth, and immune surveillance relevant to carcinogenesis. Also, epidemiologic evidence indicates that calcium and vitamin D may reduce risk for developing colorectal adenomas and cancer. To investigate the effects of calcium and vitamin D on biomarkers of inflammation in colorectal adenoma patients, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial (n = 92) of 2 g/d calcium and/or 800 IU/d vitamin D(3) supplementation versus placebo over 6 months. Plasma concentrations of proinflammatory markers [C-reactive protein (CRP), TNF-α, interleukin (IL)-6, IL-1β, and IL-8] and an anti-inflammatory marker (IL-10) were measured using ELISAs. After 6 months of treatment, in the vitamin D(3) supplementation group, CRP decreased 32% overall (P = 0.11), 37% in men (P = 0.05), and 41% among non-nonsteroidal anti-inflammatory drug (NSAID) users (P = 0.05) relative to placebo. In the vitamin D(3) supplementation group, TNF-α decreased 13%, IL-6 32%, IL-1β 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1β 27%. Although these changes were not statistically significant, a combined inflammatory markers z-score decreased 77% (P = 0.003) in the vitamin D(3) treatment group overall, 83% (P = 0.01) among men, and 48% among non-NSAID users (P = 0.01). There was no evidence of synergy between vitamin D(3) and calcium or effects on IL-10. These preliminary results are consistent with a pattern of reduction in tumor-promoting inflammation biomarkers with vitamin D(3) or calcium supplementation alone and support further investigation of vitamin D(3) as a chemopreventive agent against inflammation and colorectal neoplasms.
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