Vitamin D and type 2 diabetes: a systematic review
Mitri J, Muraru MD, Pittas AG
European journal of clinical nutrition · 362 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK76092); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK79003); National Center for Research Resources (UL1RR025752); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK079003)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2011-07-06 · Eur J Clin Nutr · vol. 65 · número 9 · págs. 1005–1015
- Editorial
- Springer Nature
- Citado
- 570 citas · más que el 98% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Nutrition and Health Studies
- Palabras clave
- vitamin D, type 2 diabetes, vitamin D supplementation, 25-hydroxyvitamin D, vitamin D intake, insulin resistance, glycemic outcomes, impaired glucose tolerance, diabetes risk
- MeSH
- humans, diabetes mellitus, type 2, glucose intolerance, insulin resistance, calcium, dietary, blood glucose, vitamins, vitamin d, data interpretation, statistical, dietary supplements, meta-analysis as topic, randomized controlled trials as topic
3 autores
- Joanna Mitri🇺🇸Tufts Medical Center
- Minerva Muraru🇺🇸Carney Hospital
- Anastassios G. Pittas🇺🇸 · autor de correspondenciaTufts Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Vitamin D may modify the risk of type 2 diabetes mellitus. The aim of this review was to examine the association between vitamin D status and incident type 2 diabetes, and the effect of vitamin D supplementation on glycemic outcomes.
Methods
We performed a systematic review of English-language studies using MEDLINE through February 2011. Longitudinal cohort studies reporting associations between vitamin D status and incident type 2 diabetes, and randomized controlled trials (RCTs) of vitamin D supplementation, were included. Study characteristics and results were extracted, and study quality was assessed.
Results
A total of 8 observational cohort studies and 11 RCTs were included. In meta-analyses of observational studies, vitamin D intake>500 international units (IU)/day decreased the risk of type 2 diabetes by 13% compared with vitamin D intake25 ng/ml) had a 43% lower risk of developing type 2 diabetes (95% confidence interval 24, 57%) compared with those in the lowest group (<14 ng/ml). In post hoc analyses from eight trials among participants with normal glucose tolerance at baseline and in three small underpowered (n=32-62) trials of patients with established type 2 diabetes, there was no effect of vitamin D supplementation on glycemic outcomes. In two trials among patients with baseline glucose intolerance, vitamin D supplementation improved insulin resistance.
Conclusions
Vitamin D may play a role in type 2 diabetes; however, to better define the role of vitamin D in the development and progression of type 2 diabetes, high-quality observational studies and RCTs that measure blood 25-hydroxyvitamin D concentration and clinically relevant glycemic outcomes are needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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