Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance
del Favero S, Roschel H, Artioli G, Ugrinowitsch C, Tricoli V, Costa A, Barroso R, Negrelli AL, Otaduy MC, da Costa Leite C, Lancha-Junior AH, Gualano B
Amino acids · 38 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
Según 1 financiador declarado.
Publicación
- Publicado
- 2011-07-08 · Amino Acids · vol. 42 · número 6 · págs. 2299–2305
- Editorial
- Springer Science+Business Media
- Citado
- 61 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Sports Performance and Training
- Palabras clave
- creatine supplementation, betaine supplementation, muscle strength, muscle power, ergogenic aids, untrained subjects, squatting, bench press, body composition, combination supplementation
- MeSH
- muscle, skeletal, humans, creatine, betaine, phosphocreatine, placebos, magnetic resonance spectroscopy, double-blind method, body composition, dietary supplements, adolescent, adult, male, muscle strength
12 autores
- Serena Menegassi Del Favero🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Guilherme Giannini Artioli🇧🇷Universidade de São Paulo
- Carlos Ugrinowitsch🇧🇷Universidade de São Paulo
- Valmor Tricoli🇧🇷Universidade de São Paulo
- André dos Santos Costa🇧🇷Universidade de São Paulo
- Renato Barroso🇧🇷Universidade de São Paulo
- Ana Lua Negrelli🇧🇷Universidade de São Paulo
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Cláudia da Costa Leite🇧🇷Universidade de São Paulo
- Antônio Herbert Lancha🇧🇷Universidade de São Paulo
- Bruno Gualano🇧🇷 · autor de correspondenciaUniversidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
We aimed to investigate the role of betaine supplementation on muscle phosphorylcreatine (PCr) content and strength performance in untrained subjects. Additionally, we compared the ergogenic and physiological responses to betaine versus creatine supplementation. Finally, we also tested the possible additive effects of creatine and betaine supplementation. This was a double-blind, randomized, placebo-controlled study. Subjects were assigned to receive betaine (BET; 2 g/day), creatine (CR; 20 g/day), betaine plus creatine (BET+CR; 2+20 g/day, respectively) or placebo (PL). At baseline and after 10 days of supplementation, we assessed muscle strength and power, muscle PCr content, and body composition. The CR and BET+CR groups presented greater increase in muscle PCr content than PL (p=0.004 and p=0.006, respectively). PCr content was comparable between BET versus PL (p=0.78) and CR versus BET+CR (p=0.99). CR and BET+CR presented greater muscle power output than PL in the squat exercise following supplementation (p=0.003 and p=0.041, respectively). Similarly, bench press average power was significantly greater for the CR-supplemented groups. CR and BET+CR groups also showed significant pre- to post-test increase in 1-RM squat and bench press (CR: p=0.027 and p<0.0001; BET+CR: p=0.03 and p<0.0001 for upper- and lower-body assessments, respectively) No significant differences for 1-RM strength and power were observed between BET versus PL and CR versus BET+CR. Body composition did not differ between the groups. In conclusion, we reported that betaine supplementation does not augment muscle PCr content. Furthermore, we showed that betaine supplementation combined or not with creatine supplementation does not affect strength and power performance in untrained subjects.
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