Effect of caffeine and taurine on simulated laparoscopy performed following sleep deprivation
Aggarwal R, Mishra A, Crochet P, Sirimanna P, Darzi A
The British journal of surgery · 39 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-07-14 · Br J Surg · vol. 98 · número 11 · págs. 1666–1672
- Editorial
- Oxford University Press
- Citado
- 62 citas · más que el 96% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Surgical Simulation and Training · Coffee research and impacts
- Palabras clave
- sleep deprivation, caffeine, taurine, laparoscopic surgery, reaction time, sleepiness, surgical performance, fatigue, virtual reality surgical simulator, cognitive performance, surgical errors, patient safety, surgical training, long working hours, Stanford Sleepiness Scale, movement economy, surgical novices
- MeSH
- humans, sleep deprivation, taurine, caffeine, central nervous system stimulants, laparoscopy, cross-over studies, single-blind method, cognition, psychomotor performance, computer simulation, general surgery, young adult
5 autores
- Rajesh K Aggarwal🇬🇧 · autor de correspondenciaImperial College London
- Amit Mishra🇬🇧Imperial College London
- Patrice Crochet🇬🇧Imperial College London
- Pramudith Sirimanna🇬🇧Imperial College London
- Ara Wardkes Darzi🇬🇧Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Sleep deprivation affects surgical performance and has the potential to endanger patient safety. Pharmacological stimulants may counter this consequence of long working hours. This study aimed to investigate whether commonly available stimulants can counter the effects of fatigue on technical and neurocognitive skill.
Methods
This was a single-blind crossover study of surgical novices trained to proficiency on the Minimally Invasive Surgical Trainer-Virtual Reality laparoscopic simulator. Participants were acutely sleep-deprived three times each, followed by administration of either placebo, 150 mg caffeine, or 150 mg caffeine combined with 2 g taurine before simulated laparoscopy. Outcome measures were: laparoscopic psychomotor skill, cognitive performance and the Stanford Sleepiness Scale (range 1-7). Rested baselines were gathered following completion of test sessions.
Results
Baseline performance was recorded for 18 participants in the rested state. Sleep-deprived participants receiving the placebo took longer (median 41 versus 35 s; P = 0·016), were less economical with movement (3·25 versus 2·95 m; P = 0·016) and made more errors (66 versus 59; P = 0·021) on the laparoscopic task compared with the rested state. Caffeine restored psychomotor skills to baseline for time taken (37 versus 35 s; P = 0·101), although the number of errors remained significantly greater than in the rested state (63 versus 59; P = 0·046). Sleep-deprived subjects receiving placebo had slower reaction times (377 versus 299 ms; P = 0·008) and a higher score on the Stanford Sleepiness Scale (6 versus 2 points; P = 0·001) than rested surgeons. Negative effects of sleep deprivation on reaction time were reversed when caffeine (307 ms versus 299 ms in rested state; P = 0·214) or caffeine plus taurine (326 versus 299 ms; P = 0·110) was administered. Subjective sleepiness was also improved, but not to baseline levels.
Conclusion
Sleep deprivation affects laparoscopic psychomotor skills, reaction time and subjective measures of sleepiness in novice surgical subjects. Caffeine and taurine restore simulated laparoscopic performance to rested levels, but do not reduce errors.
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