Effect of dietary fish oil on atrial fibrillation after cardiac surgery
Farquharson AL, Metcalf RG, Sanders P, Stuklis R, Edwards JR, Gibson RA, Cleland LG, Sullivan TR, James MJ, Young GD
The American journal of cardiology · 75 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- National Heart Foundation of Australia
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (399333)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2011-07-22 · Am J Cardiol · vol. 108 · número 6 · págs. 851–856
- Editorial
- Elsevier BV
- Citado
- 94 citas · más que el 98% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 14 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Atrial Fibrillation Management and Outcomes · Fatty Acid Research and Health · Cardiac and Coronary Surgery Techniques
- Palabras clave
- dietary fish oil, omega-3 fatty acids, atrial fibrillation, postoperative atrial fibrillation, cardiac surgery, coronary artery bypass grafting, heart valve surgery, fish oil supplementation, ICU length of stay
- MeSH
- humans, atrial fibrillation, postoperative complications, fish oils, placebos, treatment outcome, length of stay, cardiac surgical procedures, incidence, logistic models, proportional hazards models, prospective studies, double-blind method, dietary supplements, aged, middle aged, intensive care units, female, male
10 autores
- Aaron L. Farquharson🇦🇺The University of Adelaide
- Robert G. Metcalf🇦🇺 · autor de correspondenciaRoyal Adelaide Hospital; The University of Adelaide
- Prashanthan Sanders🇦🇺Royal Adelaide Hospital; The University of Adelaide
- Robert G Stuklis🇦🇺Royal Adelaide Hospital
- James R.M. Edwards🇦🇺Royal Adelaide Hospital
- Robert Alan Gibson🇦🇺The University of Adelaide
- Leslie G. Cleland🇦🇺The University of Adelaide
- Thomas Sullivan🇦🇺The University of Adelaide
- Michael J. James🇦🇺Royal Adelaide Hospital; The University of Adelaide
- Glenn D. Young🇦🇺Royal Adelaide Hospital; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
An open-label study reported that ingestion of a fish oil concentrate decreased the incidence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. However, a general cardiac surgery population involves valve and CABG surgeries. We undertook a double-blinded randomized controlled trial to examine the effectiveness of fish oil supplementation on the incidence of postsurgical AF after CABG and valve procedures. The primary end point was incidence of AF in the first 6 days after surgery. Two hundred patients were randomized to receive fish oil (providing 4.6 g/day of long-chain ω-3 fatty acids) or a control oil starting 3 weeks before surgery; 194 subjects completed the study, with 47 of 97 subjects in the control group and 36 of 97 subjects in the fish oil group developing AF (odds ratio 0.63, 95% confidence interval [CI] 0.35 to 1.11). There was a nonstatistically significant delay in time to onset of AF in the fish oil group (hazard ratio 0.66, 95% CI 0.43 to 1.01). There was a significant decrease in mean length of stay in the intensive care unit in the fish oil group (ratio of means 0.71, 95% CI 0.56 to 0.90). In conclusion, in a mixed cardiac surgery population, supplementation with dietary fish oil did not result in a significant decrease in the incidence of postsurgical AF. However, there was a significant decrease in time spent in the intensive care unit.
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