Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial
Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R
Brain, behavior, and immunity · 229 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Ohio State University
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Center for Complementary and Alternative Medicine
- Gobierno
- National Center for Research Resources
- Gobierno
- NIH Clinical Center
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCCIH NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Center for Research Resources (UL1RR025755); National Cancer Institute (CA16058); National Center for Advancing Translational Sciences (UL1TR000090); National Center for Complementary and Integrative Health (AT003912); National Center for Complementary and Integrative Health (R21 AT003912); National Cancer Institute (P30CA016058)
Según 12 financiadores declarados.
Publicación
- Publicado
- 2011-07-23 · Brain Behav Immun · vol. 25 · número 8 · págs. 1725–1734
- Editorial
- Elsevier BV
- Citado
- 337 citas · más que el 99% de estudios similares · 15.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Tryptophan and brain disorders · Nutritional Studies and Diet
- Palabras clave
- omega-3 fatty acids, n-6/n-3 ratio, inflammation, anxiety, depression, medical students, eicosapentaenoic acid, docosahexaenoic acid, interleukin-6, TNF-α, lipopolysaccharide stimulation, exam stress, young adults
- MeSH
- neutrophils, humans, inflammation, fatty acids, omega-3, fatty acids, cytokines, exercise, diet, double-blind method, sample size, depression, stress, psychological, health behavior, patient compliance, affect, anxiety, dietary supplements, adult, female, male, young adult
5 autores
- Janice K. Kiecolt‐Glaser🇺🇸 · autor de correspondenciaThe Ohio State University
- Martha Ann Belury🇺🇸The Ohio State University
- Rebecca Andridge🇺🇸The Ohio State University
- William B. Malarkey🇺🇸The Ohio State University
- Ronald Glaser🇺🇸The Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies have linked lower omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and higher omega-6 (n-6) PUFAs with inflammation and depression, but randomized controlled trial (RCT) data have been mixed. To determine whether n-3 decreases proinflammatory cytokine production and depressive and anxiety symptoms in healthy young adults, this parallel group, placebo-controlled, double-blind 12-week RCT compared n-3 supplementation with placebo. The participants, 68 medical students, provided serial blood samples during lower-stress periods as well as on days before an exam. The students received either n-3 (2.5 g/d, 2085 mg eicosapentaenoic acid and 348 mg docosahexanoic acid) or placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Compared to controls, those students who received n-3 showed a 14% decrease in lipopolysaccharide (LPS) stimulated interleukin 6 (IL-6) production and a 20% reduction in anxiety symptoms, without significant change in depressive symptoms. Individuals differ in absorption and metabolism of n-3 PUFA supplements, as well as in adherence; accordingly, planned secondary analyses that used the plasma n-6:n-3 ratio in place of treatment group showed that decreasing n-6:n-3 ratios led to lower anxiety and reductions in stimulated IL-6 and tumor necrosis factor alpha (TNF-α) production, as well as marginal differences in serum TNF-α. These data suggest that n-3 supplementation can reduce inflammation and anxiety even among healthy young adults. The reduction in anxiety symptoms associated with n-3 supplementation provides the first evidence that n-3 may have potential anxiolytic benefits for individuals without an anxiety disorder diagnosis. ClinicalTrials.gov identifier: NCT00519779.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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