Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis
Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM, Almandoz JP, Mullan RJ, Lane MA, Liu H, Erwin PJ, Hensrud DD, Montori VM
The Journal of clinical endocrinology and metabolism · 249 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-07-27 · J Clin Endocrinol Metab · vol. 96 · número 10 · págs. 2997–3006
- Editorial
- Oxford University Press
- Citado
- 390 citas · más que el 97% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D, falls, fall prevention, vitamin D deficiency, calcium supplementation, older women, bone health, muscle health
- MeSH
- humans, vitamin d deficiency, calcium, dietary, vitamin d, cluster analysis, confidence intervals, odds ratio, risk assessment, accidental falls, nutritional status, publication bias, aged, aged, 80 and over, female, male, randomized controlled trials as topic
13 autores
- Mohammad Hassan Murad🇺🇸 · autor de correspondenciaMayo Clinic
- Khalid B. Elamin🇺🇸MetroHealth Medical Center; Case Western Reserve University
- Nisrin O. Abu Elnour🇺🇸Mayo Clinic
- Mohamed B. Elamin🇺🇸Mayo Clinic
- Aziz A. Alkatib🇺🇸Mayo Clinic
- Mitra M. Fatourechi🇺🇸Mayo Clinic
- Jaime P. Almandoz🇺🇸Mayo Clinic
- Rebecca J. Mullan🇺🇸Mayo Clinic
- Melanie A. Lane🇺🇸Mayo Clinic
- Hau Liu🇺🇸Santa Clara Valley Medical Center
- Patricia J. Erwin🇺🇸Mayo Clinic
- Donald D. Hensrud🇺🇸Mayo Clinic
- Víctor M. Montori🇺🇸Mayo Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Vitamin D affects bone and muscle health and likely reduces the risk of falls in the elderly.
Objective
The aim of this systematic review is to summarize the existing evidence on vitamin D use and the risk of falls.
Data sources
We searched electronic databases from inception through August 2010.
Study selection
Eligible studies were randomized controlled trials in which the intervention was vitamin D and the incidence of falls was reported.
Data extraction
Reviewers working in duplicate and independently extracted study characteristics, quality, and outcomes data.
Data synthesis
Odds ratio and associated 95% confidence interval were estimated from each study and pooled using the random effects model.
Results
We found 26 eligible trials of moderate quality that enrolled 45,782 participants, the majority of which were elderly and female. Vitamin D use was associated with statistically significant reduction in the risk of falls (odds ratio for suffering at least one fall, 0.86; 95% confidence interval, 0.77-0.96). This effect was more prominent in patients who were vitamin D deficient at baseline and in studies in which calcium was coadministered with vitamin D. The quality of evidence was low to moderate because of heterogeneity and publication bias.
Conclusions
Vitamin D combined with calcium reduces the risk of falls. The reduction in studies without calcium coadministration did not reach statistical significance. The majority of the evidence is derived from trials enrolling elderly women.
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