Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects
Siqueira J, Smiley D, Newton C, Le NA, Gosmanov AR, Spiegelman R, Peng L, Osteen SJ, Jones DP, Quyyumi AA, Ziegler TR, Umpierrez GE
The Journal of clinical endocrinology and metabolism · 37 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1 TR000454); National Center for Research Resources (K24 RR023356); National Center for Research Resources (UL1RR025008)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2011-08-11 · J Clin Endocrinol Metab · vol. 96 · número 10 · págs. 3207–3216
- Editorial
- Oxford University Press
- Citado
- 55 citas · más que el 95% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Central Venous Catheters and Hemodialysis
- Palabras clave
- parenteral nutrition, Intralipid, ClinOleic, omega-6 fatty acids, endothelial dysfunction, flow-mediated dilation, blood pressure, insulin response, glucose, oxidative stress, inflammatory markers, immune function, sympathetic activity, nutritional support
- MeSH
- blood vessels, endothelium, vascular, autonomic nervous system, sympathetic nervous system, humans, inflammation, insulin, c-peptide, blood glucose, lipids, soybean oil, fat emulsions, intravenous, fatty acids, nonesterified, plant oils, parenteral nutrition, dilatation, immunity, metabolism, oxidative stress, blood pressure, heart rate, food, formulated, adult, middle aged, female, male, olive oil
12 autores
- Joselita Siqueira🇺🇸Emory University
- Dawn D. Smiley🇺🇸Emory University
- Christopher R. Newton🇺🇸Emory University
- Ngoc‐Anh Le🇺🇸Emory University; Atlanta VA Medical Center
- Aidar R. Gosmanov🇺🇸University of Tennessee Health Science Center
- Ronnie Spiegelman🇺🇸Emory University
- Limin Peng🇺🇸Emory University
- Samantha J. Osteen🇺🇸Emory University
- Dean P. Jones🇺🇸Emory University
- Arshed Ali Quyyumi🇺🇸Emory University
- Thomas R. Ziegler🇺🇸Emory University
- Guillermo E. Umpierrez🇺🇸 · autor de correspondenciaEmory University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Soybean oil-based lipid emulsions are the only Food and Drug Administration-approved lipid formulation for clinical use in parenteral nutrition (PN). Recently concerns with its use have been raised due to the proinflammatory effects that may lead to increased complications because they are rich in ω-6 polyunsaturated fatty acids.
Methods
This was a prospective, randomized, controlled, crossover study comparing the vascular, metabolic, immune, and inflammatory effects of 24-h infusion of PN containing soybean oil-based lipid emulsion (Intralipid), olive oil-based (ClinOleic), lipid free, and normal saline in 12 healthy subjects.
Results
Soybean oil-PN increased systolic blood pressure compared with olive oil-PN (P < 0.05). Soybean oil PN reduced brachial artery flow-mediated dilatation from baseline (-23% at 4 h and -25% at 24 h, both P < 0.01); in contrast, olive oil PN, lipid free PN, and saline did not change either systolic blood pressure or flow-mediated dilatation. Compared with saline, soybean oil PN, olive oil PN, and lipid free PN similarly increased glucose and insulin concentrations during infusion (P < 0.05). There were no significant changes in plasma free fatty acids, lipid profile, inflammatory and oxidative stress markers, immune function parameters, or sympathetic activity between soybean oil- and olive oil-based lipid emulsions.
Conclusion
The 24-h infusion of PN containing soybean oil-based lipid emulsion increased blood pressure and impaired endothelial function compared with PN containing olive oil-based lipid emulsion and lipid-free PN in healthy subjects. These vascular changes may have significant implications in worsening outcome in subjects receiving nutrition support. Randomized controlled trials with relevant clinical outcome measures are needed in patients receiving PN with olive oil-based and soybean oil-based lipid emulsions.
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