A multicentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients
Brignole-Baudouin F, Baudouin C, Aragona P, Rolando M, Labetoulle M, Pisella PJ, Barabino S, Siou-Mermet R, Creuzot-Garcher C
Acta ophthalmologica · 93 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-08-11 · Acta Ophthalmol · vol. 89 · número 7 · págs. e591–e597
- Editorial
- Wiley
- Citado
- 133 citas · más que el 98% de estudios similares · 10.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ocular Surface and Contact Lens · Fatty Acid Research and Health · Retinal Diseases and Treatments
- Palabras clave
- dry eye, omega-3 fatty acids, omega-6 fatty acids, dietary supplementation, HLA-DR, conjunctival inflammation, imprint cytology, conjunctival epithelium, anti-inflammatory activity
- MeSH
- conjunctiva, humans, dry eye syndromes, fatty acids, omega-3, fatty acids, omega-6, hla-dr antigens, antioxidants, fluorophotometry, administration, oral, double-blind method, quality of life, dietary supplements, middle aged, female, male, biomarkers, surveys and questionnaires
9 autores
- Françoise Brignole‐Baudouin🇫🇷 · autor de correspondenciaCentre National de la Recherche Scientifique; Institut de la Vision; Inserm; Université Paris Descartes; Université Pierre-et-Marie-Curie
- Christophe Baudouin🇫🇷Centre National de la Recherche Scientifique; Institut de la Vision; Inserm; Centre hospitalier national d'ophtalmologie des Quinze-Vingts; Université Pierre-et-Marie-Curie
- Pasquale Aragona🇮🇹University of Messina
- Maurizio Rolando🇮🇹University of Genoa
- Marc Labétoulle🇫🇷Bicêtre Hospital
- Pierre Jean Pisella🇫🇷Université de Tours; Hôpital Bretonneau
- Stefano Barabino🇮🇹University of Genoa
- Raphaele Siou-Mermet🇫🇷Bausch & Lomb (France)
- Catherine P Creuzot-Garcher
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To determine whether oral supplementation with omega-3 and omega-6 fatty acids can reduce conjunctival epithelium expression of the inflammatory marker human leucocyte antigen-DR (HLA-DR) in patients with dry eye syndrome (DES).
Methods
This 3-month, double-masked, parallel-group, controlled study was conducted in nine centres, in France and Italy. Eligible adult patients with mild to moderate DES were randomized to receive a placebo containing medium-chain triglycerides or treatment supplement containing omega-3 and omega-6 fatty acids, vitamins and zinc. Treatment regimen was three capsules daily. Impression cytology (IC) was performed at baseline and at month 3 to assess the percentage of cells expressing HLA-DR and to evaluate fluorescence intensity, an alternate measure of HLA-DR. Dry eye symptoms and objective signs were also evaluated. Analyses were performed on the full analysis set (FAS) and per-protocol set (PPS).
Results
In total, 138 patients were randomized; 121 patients with available IC were included in the FAS, and of these, 106 patients had no major protocol deviations (PPS). In the PPS, there was a significant reduction in the percentage of HLA-DR-positive cells in the fatty acids group (p = 0.021). Expression of HLA-DR as measured by fluorescence intensity quantification was also significantly reduced in the fatty acids group [FAS (p = 0.041); PPS (p = 0.017)]. No significant difference was found for the signs and symptoms, but there was a tendency for improvement in patients receiving the fatty acids treatment.
Conclusion
This study demonstrates that supplementation with omega-3 and omega-6 fatty acids can reduce expression of HLA-DR conjunctival inflammatory marker and may help improve DES symptoms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.