Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age
Campoy C, Escolano-Margarit MV, Ramos R, Parrilla-Roure M, Csábi G, Beyer J, Ramirez-Tortosa MC, Molloy AM, Decsi T, Koletzko BV
The American journal of clinical nutrition · 75 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2011-08-18 · Am J Clin Nutr · vol. 94 · número 6 Suppl · págs. S1880–S1888
- Editorial
- Elsevier BV
- Citado
- 112 citas · más que el 97% de estudios similares · 7.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Child Nutrition and Water Access
- Palabras clave
- prenatal supplementation, fish oil, omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, 5-methyltetrahydrofolate, folic acid, long-chain polyunsaturated fatty acids, child cognitive development, brain development, maternal nutrition, infant formula, Kaufman Assessment Battery for Children
- MeSH
- humans, folic acid, tetrahydrofolates, docosahexaenoic acids, eicosapentaenoic acid, arachidonic acid, fish oils, cohort studies, follow-up studies, child development, cognition, pregnancy, pregnancy trimester, third, dietary supplements, child, infant, female, male, infant nutritional physiological phenomena, maternal nutritional physiological phenomena
10 autores
- Cristina Campoy🇪🇸 · autor de correspondenciaUniversidad de Granada
- María Victoria Escolano-Margarit🇪🇸Universidad de Granada
- Rosa Ramos🇪🇸Universidad de Granada; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Montserrat Parrilla‐Roure🇪🇸Universidad de Granada
- Györgyi Csábí🇭🇺University of Pecs
- Jeannette Beyer🇩🇪Ludwig-Maximilians-Universität München
- M. Carmen Ramírez-Tortosa🇪🇸Universidad de Granada
- Anne Marie Molloy🇮🇪Trinity College Dublin
- Támas Décsi🇪🇸🇭🇺Universidad de Granada; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; University of Pecs
- Berthold Viktor Koletzko🇪🇸🇩🇪Universidad de Granada; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The influence of prenatal long-chain polyunsaturated fatty acids (LC-PUFAs) and folate on neurologic development remains controversial.
Objective
The objective was to assess the long-term effects of n-3 (omega-3) LC-PUFA supplementation, 5-methyltetrahydrofolate (5-MTHF) supplementation, or both in pregnant women on cognitive development of offspring at 6.5 y of age.
Design
This was a follow-up study of the NUHEAL (Nutraceuticals for a Healthier Life) cohort. Healthy pregnant women in 3 European centers were randomly assigned to 4 intervention groups. From the 20th week of pregnancy until delivery, they received a daily supplement of 500 mg docosahexaenoic acid (DHA) + 150 mg eicosapentaenoic acid [fish oil (FO)], 400 μg 5-MTHF, or both or a placebo. Infants received formula containing 0.5% DHA and 0.4% arachidonic acid (AA) if they were born to mothers receiving FO supplements or were virtually free of DHA and AA until the age of 6 mo if they belonged to the groups that were not supplemented with FO. Fatty acids and folate concentrations were determined in maternal blood at weeks 20 and 30 of pregnancy, at delivery, and in cord blood. Cognitive function was assessed at 6.5 y of age with the Kaufman Assessment Battery for Children (K-ABC).
Results
We observed no significant differences in K-ABC scores between intervention groups. Higher DHA in maternal erythrocytes at delivery was associated with a Mental Processing Composite Score higher than the 50th percentile in the offspring.
Conclusion
We observed no significant effect of supplementation on the cognitive function of children, but maternal DHA status may be related to later cognitive function in children. This trial was registered at clinicaltrials.gov as NCT01180933.
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