Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil
Schuchardt JP, Schneider I, Meyer H, Neubronner J, von Schacky C, Hahn A
Lipids in health and disease · 198 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Universidad u hospital
- Gottfried Wilhelm Leibniz Universität Hannover
- Universidad u hospital
- Ludwig-Maximilians-Universität München
- Universidad u hospital
- Leibniz-Gemeinschaft
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2011-01-01 · Lipids Health Dis · vol. 10 · número 1 · pág. 145
- Editorial
- BioMed Central
- Citado
- 291 citas · más que el 100% de estudios similares · 17.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, EPA, docosahexaenoic acid, bioavailability, krill oil, fish oil, ethyl esters, free fatty acids, plasma phospholipids, n-3 long-chain polyunsaturated fatty acids, dietary supplement formulation, healthy young men, crossover trial
- MeSH
- animals, humans, euphausiacea, docosahexaenoic acids, eicosapentaenoic acid, phospholipids, fish oils, area under curve, double-blind method, chemistry, pharmaceutical, adult, male
6 autores
- Jan Philipp Schuchardt🇩🇪 · autor de correspondenciaLeibniz University Hannover
- Inga Schneider🇩🇪Leibniz University Hannover
- Henrike Meyer🇩🇪Leibniz University Hannover
- Juliane Neubronner🇩🇪Leibniz University Hannover
- Clemens von Schacky🇩🇪Ludwig-Maximilians-Universität München
- Andreas Hahn🇩🇪Leibniz University Hannover
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Bioavailability of omega-3 fatty acids (FA) depends on their chemical form. Superior bioavailability has been suggested for phospholipid (PL) bound omega-3 FA in krill oil, but identical doses of different chemical forms have not been compared.
Methods
In a double-blinded crossover trial, we compared the uptake of three EPA+DHA formulations derived from fish oil (re-esterified triacylglycerides [rTAG], ethyl-esters [EE]) and krill oil (mainly PL). Changes of the FA compositions in plasma PL were used as a proxy for bioavailability. Twelve healthy young men (mean age 31 y) were randomized to 1680 mg EPA+DHA given either as rTAG, EE or krill oil. FA levels in plasma PL were analyzed pre-dose and 2, 4, 6, 8, 24, 48, and 72 h after capsule ingestion. Additionally, the proportion of free EPA and DHA in the applied supplements was analyzed.
Results
The highest incorporation of EPA+DHA into plasma PL was provoked by krill oil (mean AUC0-72 h: 80.03 ± 34.71%*h), followed by fish oil rTAG (mean AUC0-72 h: 59.78 ± 36.75%*h) and EE (mean AUC0-72 h: 47.53 ± 38.42%*h). Due to high standard deviation values, there were no significant differences for DHA and the sum of EPA+DHA levels between the three treatments. However, a trend (p = 0.057) was observed for the differences in EPA bioavailability. Statistical pair-wise group comparison's revealed a trend (p = 0.086) between rTAG and krill oil. FA analysis of the supplements showed that the krill oil sample contained 22% of the total EPA amount as free EPA and 21% of the total DHA amount as free DHA, while the two fish oil samples did not contain any free FA.
Conclusion
Further studies with a larger sample size carried out over a longer period are needed to substantiate our findings and to determine differences in EPA+DHA bioavailability between three common chemical forms of LC n-3 FA (rTAG, EE and krill oil). The unexpected high content of free EPA and DHA in krill oil, which might have a significant influence on the availability of EPA+DHA from krill oil, should be investigated in more depth and taken into consideration in future trials.
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