Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies
Dong JY, Xun P, He K, Qin LQ
Diabetes care · 230 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (30771808)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2011-08-19 · Diabetes Care · vol. 34 · número 9 · págs. 2116–2122
- Editorial
- American Diabetes Association
- Citado
- 351 citas · más que el 100% de estudios similares · 17.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, type 2 diabetes, diabetes risk, dose-response relationship, overweight, cereal fiber, prospective cohort
- MeSH
- humans, diabetes mellitus, type 2, magnesium, prospective studies, dose-response relationship, drug
4 autores
- Jia-Yi Dong🇨🇳Soochow University
- Pengcheng Xun🇺🇸University of North Carolina at Chapel Hill
- Ka He🇺🇸University of North Carolina at Chapel Hill
- Li‐Qiang Qin🇨🇳 · autor de correspondenciaSoochow University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.
Research design and methods
We conducted a PubMed database search through January 2011 to identify prospective cohort studies of magnesium intake and risk of type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates.
Results
Meta-analysis of 13 prospective cohort studies involving 536,318 participants and 24,516 cases detected a significant inverse association between magnesium intake and risk of type 2 diabetes (relative risk [RR] 0.78 [95% CI 0.73-0.84]). This association was not substantially modified by geographic region, follow-up length, sex, or family history of type 2 diabetes. A significant inverse association was observed in overweight (BMI ≥25 kg/m(2)) but not in normal-weight individuals (BMI <25 kg/m(2)), although test for interaction was not statistically significant (P(interaction) = 0.13). In the dose-response analysis, the summary RR of type 2 diabetes for every 100 mg/day increment in magnesium intake was 0.86 (95% CI 0.82-0.89). Sensitivity analyses restricted to studies with adjustment for cereal fiber intake yielded similar results. Little evidence of publication bias was observed.
Conclusions
This meta-analysis provides further evidence supporting that magnesium intake is significantly inversely associated with risk of type 2 diabetes in a dose-response manner.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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