Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies
Ma Y, Zhang P, Wang F, Yang J, Liu Z, Qin H
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 278 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Shanghai Rising-Star Program
- Subvenciones
- National Natural Science Foundation of China (81001069)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-08-30 · J Clin Oncol · vol. 29 · número 28 · págs. 3775–3782
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 385 citas · más que el 95% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Colorectal Cancer Screening and Detection
- Palabras clave
- vitamin D, colorectal cancer, 25-hydroxyvitamin D, vitamin D intake, colon cancer, rectal cancer, cancer risk, serum vitamin D levels
- MeSH
- humans, colorectal neoplasms, vitamin d, risk factors, case-control studies, cohort studies, prospective studies, female, male
6 autores
- Yanlei Ma🇨🇳Shanghai Jiao Tong University; Shanghai Sixth People's Hospital
- Peng Zhang🇨🇳Shanghai Jiao Tong University; Shanghai Sixth People's Hospital
- Feng Wang🇨🇳Shanghai Jiao Tong University; Shanghai Sixth People's Hospital
- Jianjun Yang🇨🇳Shanghai Jiao Tong University; Shanghai Sixth People's Hospital
- Zhihua Liu🇨🇳Shanghai Jiao Tong University; Shanghai Sixth People's Hospital
- Huanlong Qin🇨🇳Shanghai Jiao Tong University; Shanghai Sixth People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis.
Methods
Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis.
Results
Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89).
Conclusion
Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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