Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data set
Bolland MJ, Grey A, Gamble GD, Reid IR
The American journal of clinical nutrition · 186 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Women's Health Initiative
- Universidad u hospital
- University of Auckland
- Gobierno
- Health Research Council of New Zealand
- Gobierno
- National Heart, Lung, and Blood Institute
Según 4 financiadores declarados.
Publicación
- Publicado
- 2011-09-01 · Am J Clin Nutr · vol. 94 · número 4 · págs. 1144–1149
- Editorial
- Elsevier BV
- Citado
- 260 citas · más que el 100% de estudios similares · 20.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutrition and Health Studies
- Palabras clave
- calcium supplements, vitamin D supplements, Women's Health Initiative, postmenopausal women, breast cancer, colorectal cancer, cancer risk, fracture risk, mortality
- MeSH
- humans, neoplasms, breast neoplasms, colorectal neoplasms, hip fractures, calcium, dietary, vitamin d, self care, incidence, mortality, proportional hazards models, risk, postmenopause, dietary supplements, aged, middle aged, united states, female, fractures, bone, confounding factors, epidemiologic
4 autores
- Mark J Bolland🇳🇿 · autor de correspondenciaUniversity of Auckland
- Andrew B. Grey🇳🇿University of Auckland
- Greg D. Gamble🇳🇿University of Auckland
- Ian R. Reid🇳🇿University of Auckland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Frequent use of personal, nonprotocol calcium supplements obscured an adverse effect of coadministered calcium and vitamin D (CaD) on cardiovascular risk in the Women's Health Initiative (WHI).
Objective
We investigated the effects of the use of personal calcium or vitamin D supplements on other outcomes in the WHI CaD Study (WHI CaD) by using the WHI limited-access clinical trials data set.
Design
The WHI CaD was a 7-y, randomized, placebo-controlled trial of CaD (1 g Ca/400 IU vitamin D daily) in 36,282 community-dwelling, postmenopausal women. The incidence of total cancer (excluding nonmelanoma skin cancers), breast and colorectal cancers, hip and total fracture, and mortality was assessed by using Cox proportional hazards models.
Results
In the WHI CaD, interactions between the use of either personal calcium or vitamin D supplements and CaD were found for total, breast, and colorectal cancers but not for fracture or mortality. In 15,646 women (43%) who were not taking personal calcium or vitamin D supplements at randomization, CaD significantly decreased the risk of total, breast, and invasive breast cancers by 14-20% and nonsignificantly reduced the risk of colorectal cancer by 17%. In women taking personal calcium or vitamin D supplements, CaD did not alter cancer risk (HR: 1.06-1.26).
Conclusions
For women in the WHI CaD who were not taking personal calcium or vitamin D supplements at randomization, CaD decreased the risk of total, breast, and colorectal cancers and did not change the risk of fractures or total mortality. The nonskeletal effects of CaD may be more important than the skeletal effects and should be considered when evaluating these supplements. The WHI CaD trial is registered at clinicaltrials.gov as NCT00000611.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.