Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study
Lankinen M, Schwab U, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Uusitupa M, Orešič M
PloS one · 77 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- European Commission
- Gobierno
- Tekes
- Universidad u hospital
- Kuopion Yliopistollinen Sairaala
- Organización sin fines de lucro
- Diabetestutkimussäätiö
- Subvenciones
- European Commission (FOOD-CT-2005-514008); European Commission (FOOD-CT-2005); Tekes (070014)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2011-08-25 · PLoS One · vol. 6 · número 8 · pág. e22646
- Editorial
- Public Library of Science
- Citado
- 103 citas · más que el 99% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- whole grains, fatty fish, Vaccinium myrtillus, glucose metabolism, lipid metabolism, impaired glucose tolerance, metabolic syndrome, type 2 diabetes prevention, plasma lipidomics, n-3 long-chain polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, insulin secretion, glucose disposal, dietary intervention
- MeSH
- humans, vaccinium myrtillus, diabetes mellitus, type 2, blood glucose, fatty acids, omega-3, fish products, aged, middle aged, female, male, lipid metabolism, edible grain
10 autores
- Maria Anneli Lankinen🇫🇮 · autor de correspondenciaUniversity of Eastern Finland; VTT Technical Research Centre of Finland
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
- Marjukka Kolehmainen🇫🇮University of Eastern Finland
- Jussi Paananen🇫🇮University of Eastern Finland
- Kaisa S Poutanen🇫🇮University of Eastern Finland; VTT Technical Research Centre of Finland
- Hannu M Mykkänen🇫🇮University of Eastern Finland
- Tuulikki Seppänen‐Laakso🇫🇮VTT Technical Research Centre of Finland
- Helena K. Gylling🇫🇮University of Eastern Finland; Kuopio University Hospital
- Matti I.J. Uusitupa🇫🇮University of Eastern Finland; Kuopio University Hospital
- Matej Orešič🇫🇮VTT Technical Research Centre of Finland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Due to the growing prevalence of type 2 diabetes, new dietary solutions are needed to help improve glucose and lipid metabolism in persons at high risk of developing the disease. Herein we investigated the effects of low-insulin-response grain products, fatty fish, and berries on glucose metabolism and plasma lipidomic profiles in persons with impaired glucose metabolism.
Methodology/principal findings
Altogether 106 men and women with impaired glucose metabolism and with at least two other features of the metabolic syndrome were included in a 12-week parallel dietary intervention. The participants were randomized into three diet intervention groups: (1) whole grain and low postprandial insulin response grain products, fatty fish three times a week, and bilberries three portions per day (HealthyDiet group), (2) Whole grain enriched diet (WGED) group, which includes principally the same grain products as group (1), but with no change in fish or berry consumption, and (3) refined wheat breads (Control). Oral glucose tolerance, plasma fatty acids and lipidomic profiles were measured before and after the intervention. Self-reported compliance with the diets was good and the body weight remained constant. Within the HealthyDiet group two hour glucose concentration and area-under-the-curve for glucose decreased and plasma proportion of (n-3) long-chain PUFAs increased (False Discovery Rate p-values <0.05). Increases in eicosapentaenoic acid and docosahexaenoic acid associated curvilinearly with the improved insulin secretion and glucose disposal. Among the 364 characterized lipids, 25 changed significantly in the HealthyDiet group, including multiple triglycerides incorporating the long chain (n-3) PUFA.
Conclusions/significance
The results suggest that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons.
Trial registration
ClinicalTrials.gov NCT00573781.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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