The effects of high- and low-dose aspirin on thermoregulation during and after acute cold exposure
Murray LK, Otterstetter R, Muller MD, Glickman EL
Wilderness & environmental medicine · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kent State University
- Organización sin fines de lucro
- Wellcome Trust
- Universidad u hospital
- Research and Graduate Studies at Kent State University
- Subvenciones
- Wellcome Trust (087520)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2011-09-11 · Wilderness Environ Med · vol. 22 · número 4 · págs. 321–325
- Editorial
- Elsevier BV
- Citado
- 5 citas · más que el 60% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Thermal Regulation in Medicine · High Altitude and Hypoxia
- Palabras clave
- aspirin, thermoregulation, acute cold exposure, rewarming, rectal temperature, skin temperature, thermogenesis, low-dose aspirin, high-dose aspirin, cold acclimation
- MeSH
- humans, aspirin, anti-inflammatory agents, non-steroidal, analysis of variance, cross-over studies, body temperature regulation, dose-response relationship, drug, time factors, adult, male, cold temperature
4 autores
- Leigh K. Murray🇺🇸 · autor de correspondenciaKent State University; Walsh University
- Ronald Otterstetter🇺🇸University of Akron; Kent State University
- Matthew David Muller🇺🇸Kent State University; Penn State Milton S. Hershey Medical Center
- Ellen L. Glickman🇺🇸Kent State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes.
Methods
Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO(2) and body composition. Participants underwent 3 trials in which they ingested the following for 1 week prior to each experimental trial: a capsule filled with cellulose (placebo), 81 mg · day(-1) of aspirin (low-dose aspirin), or 650 mg · day(-1) of aspirin (high-dose aspirin). Each trial consisted of a 30-minute baseline period, 120 minutes of exposure to 12°C air, and 120 minutes of recovery in 25°C air. Mean skin temperature and rectal temperature (T(re)) were measured, and heat production was calculated.
Results
During both acute cold exposure and rewarming, analysis of variance revealed a main effect for time (P < .05) with respect to T(re), mean skin temperature, and heat production. However, there were no significant differences between the treatments or treatment by time interactions.
Conclusions
These data demonstrate that aspirin had no significant effect on the thermal and metabolic responses during acute cold exposure and rewarming.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.