Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder
Cramer JM, Teran-Garcia M, Jeffery EH
The British journal of nutrition · 31 citas
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Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-09-13 · Br J Nutr · vol. 107 · número 9 · págs. 1333–1338
- Editorial
- Cambridge University Press
- Citado
- 55 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Nitrogen and Sulfur Effects on Brassica
- Palabras clave
- sulforaphane, glucoraphanin, broccoli sprouts, myrosinase, isothiocyanates, bioavailability, urinary excretion, dietary supplements, chemoprevention, thioglucosides
- MeSH
- humans, brassica, neoplasms, oximes, imidoesters, isothiocyanates, sulfoxides, glucosinolates, acetylcysteine, anticarcinogenic agents, powders, diet, cross-over studies, absorption, hydrolysis, dietary supplements, adolescent, adult, male, nutritional sciences, young adult, biomarkers, surveys and questionnaires
3 autores
- Jenna M. Cramer🇺🇸University of Illinois Urbana-Champaign
- Margarita Terán-Garcı́a🇺🇸University of Illinois Urbana-Champaign
- Elizabeth H. Jeffery🇺🇸 · autor de correspondenciaUniversity of Illinois Urbana-Champaign
Resumen
El texto original del estudio, en el idioma en que se publicó.
Sulforaphane (SF) is a chemopreventive isothiocyanate (ITC) derived from glucoraphanin (GRP) hydrolysis by myrosinase, a thioglucoside present in broccoli. The ability of broccoli powders sold as supplements to provide dietary SF is often of concern as many supplements contain GRP, but lack myrosinase. In a previous study, biomarkers of SF bioavailability from a powder rich in GRP, but lacking myrosinase, were enhanced by co-consumption of a myrosinase-containing air-dried broccoli sprout powder. Here, we studied the absorption of SF from the GRP-rich powder used in the previous study, but in combination with fresh broccoli sprouts, which are commercially available and more applicable to the human diet than air-dried sprout powder. A total of four participants each consumed four meals (separated by 1 week) consisting of dry cereal and yogurt with sprouts equivalent to 70 μmol SF, GRP powder equivalent to 120 μmol SF, both or neither. Metabolites of SF were analysed in blood and urine. The 24 h urinary SF-N-acetylcysteine recovery was 65, 60 and 24 % of the dose ingested from combination, broccoli sprout and GRP powder meals, respectively. In urine and plasma, ITC appearance was delayed following the GRP powder meal compared with the sprout and combination meals. Compared with the GRP powder or sprouts alone, combining broccoli sprouts with the GRP powder synergistically enhanced the early appearance of SF, offering insight into the combination of foods for improved health benefits of foods that reduce the risk for cancer.
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