Evaluation of low-level laser therapy in the prevention and treatment of radiation-induced mucositis: a double-blind randomized study in head and neck cancer patients
Carvalho PA, Jaguar GC, Pellizzon AC, Prado JD, Lopes RN, Alves FA
Oral oncology · 71 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-09-12 · Oral Oncol · vol. 47 · número 12 · págs. 1176–1181
- Editorial
- Elsevier BV
- Citado
- 116 citas · más que el 97% de estudios similares · 6.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, radiation-induced mucositis, oral mucositis, head and neck cancer, radiotherapy complications, oropharyngeal cancer, oral pain, 660 nm laser, mucositis prevention
- MeSH
- humans, mouth neoplasms, oropharyngeal neoplasms, pain, radiation injuries, pain measurement, treatment outcome, radiotherapy, conformal, prospective studies, double-blind method, adult, aged, aged, 80 and over, middle aged, female, male, radiotherapy, intensity-modulated, mucositis, lasers, semiconductor, young adult, low-level light therapy
6 autores
- PAULO ANDRÉ GONÇALVES DE CARVALHO🇧🇷AC Camargo Hospital
- Graziella Chagas Jaguar🇧🇷AC Camargo Hospital
- Antônio Cássio Assis Pellizzon🇧🇷AC Camargo Hospital
- José Divaldo Prado🇧🇷AC Camargo Hospital
- Rodrigo Nascimento Lopes🇧🇷AC Camargo Hospital
- Fábio Abreu Alves🇧🇷 · autor de correspondenciaUniversidade de São Paulo; AC Camargo Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this prospective study was to determine the effect of the low-level laser in the prevention and treatment of mucositis in head and neck cancer patients. A total of 70 patients with malignant neoplasms in the oral cavity or oropharynx were evaluated. The patients were randomized into two low-level laser therapy groups: Group 1 (660nm/15mW/3.8J/cm(2)/spot size 4mm(2)) or Group 2 (660nm/5mW/1.3J/cm(2)/spot size 4mm(2)) starting on the first day of radiotherapy. Oral mucositis was assessed daily and weekly using the NCI and WHO scales. Oral pain was scored daily with a visual analogue scale before laser application. The patients in Group 1 had a mean time of 13.5days (range 6-26days) to present mucositis grade II, while the patients in Group 2 had a mean time of 9.8days (range 4-14days) (both WHO and NCI p=0.005). In addition, Group 2 also presented a higher mucositis grade than Group 1 with significant differences found in weeks 2 (p=0.019), 3 (p=0.005) and 4 (p=0.003) for WHO scale and weeks 2 (p=0.009) and 4 (p=0.013) for NCI scale. The patients in Group 1 reported lower pain levels (p=0.004). Low-level laser therapy during radiotherapy was found to be effective in controlling the intensity of mucositis and pain.
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