Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia
Vanhatalo A, Fulford J, Bailey SJ, Blackwell JR, Winyard PG, Jones AM
The Journal of physiology · 165 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-09-13 · J Physiol · vol. 589 · número 22 · págs. 5517–5528
- Editorial
- Wiley
- Citado
- 229 citas · más que el 99% de estudios similares · 13.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- High Altitude and Hypoxia · Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control
- Palabras clave
- Hypoxia (environmental), Internal medicine, Nitrate, Cardiology, Medicine, Endocrinology, Dietary Nitrate, Chemistry, Oxygen
- MeSH
- muscle, skeletal, humans, beta vulgaris, plant roots, nitrates, nitrites, plant extracts, exercise test, cross-over studies, double-blind method, blood pressure, exercise tolerance, dietary supplements, adult, female, male, young adult, hypoxia
6 autores
- Anni Vanhatalo🇬🇧University of Exeter
- Jonathan Fulford🇺🇸Peninsula Research
- Stephen J. Bailey
- James R. Blackwell
- Paul Graham Winyard🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- ANDREW MARK JONES
Resumen
El texto original del estudio, en el idioma en que se publicó.
Exercise in hypoxia is associated with reduced muscle oxidative function and impaired exercise tolerance. We hypothesised that dietary nitrate supplementation (which increases plasma [nitrite] and thus NO bioavailability) would ameliorate the adverse effects of hypoxia on muscle metabolism and oxidative function. In a double-blind, randomised crossover study, nine healthy subjects completed knee-extension exercise to the limit of tolerance (T(lim)), once in normoxia (20.9% O(2); CON) and twice in hypoxia (14.5% O(2)). During 24 h prior to the hypoxia trials, subjects consumed 0.75 L of nitrate-rich beetroot juice (9.3 mmol nitrate; H-BR) or 0.75 L of nitrate-depleted beetroot juice as a placebo (0.006 mmol nitrate; H-PL). Muscle metabolism was assessed using calibrated (31)P-MRS. Plasma [nitrite] was elevated (P < 0.01) following BR (194 ± 51 nm) compared to PL (129 ± 23 nm) and CON (142 ± 37 nM). T(lim) was reduced in H-PL compared to CON (393 ± 169 vs. 471 ± 200 s; P < 0.05) but was not different between CON and H-BR (477 ± 200 s). The muscle [PCr], [P(i)] and pH changed at a faster rate in H-PL compared to CON and H-BR. The [PCr] recovery time constant was greater (P < 0.01) in H-PL (29 ± 5 s) compared to CON (23 ± 5 s) and H-BR (24 ± 5 s). Nitrate supplementation reduced muscle metabolic perturbation during exercise in hypoxia and restored exercise tolerance and oxidative function to values observed in normoxia. The results suggest that augmenting the nitrate-nitrite-NO pathway may have important therapeutic applications for improving muscle energetics and functional capacity in hypoxia.
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