Vitamin D, insulin secretion, sensitivity, and lipids: results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique
Grimnes G, Figenschau Y, Almås B, Jorde R
Diabetes · 97 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Haukeland Universitetssjukehus
Según 1 financiador declarado.
Publicación
- Publicado
- 2011-09-13 · Diabetes · vol. 60 · número 11 · págs. 2748–2757
- Editorial
- American Diabetes Association
- Citado
- 125 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins · Magnesium in Health and Disease
- Palabras clave
- vitamin D deficiency, vitamin D supplementation, 25-hydroxyvitamin D, insulin sensitivity, insulin secretion, hyperglycemic clamp, triglycerides, HbA1c, serum lipids, healthy volunteers
- MeSH
- humans, carbohydrate metabolism, inborn errors, hyperglycemia, insulin resistance, vitamin d deficiency, cholecalciferol, calcifediol, insulin, glycerol kinase, lipids, triglycerides, capsules, glucose clamp technique, case-control studies, dietary supplements, adult, aged, middle aged, female, male, hypoadrenocorticism, familial, insulin secretion, glycated hemoglobin
4 autores
- Guri Grimnes🇳🇴 · autor de correspondenciaUniversity Hospital of North Norway; UiT The Arctic University of Norway
- Yngve Figenschau🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Bjørg Almås🇳🇴Haukeland University Hospital
- Rolf Jorde🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Vitamin D deficiency is associated with an unfavorable metabolic profile in observational studies. The intention was to compare insulin sensitivity (the primary end point) and secretion and lipids in subjects with low and high serum 25(OH)D (25-hydroxyvitamin D) levels and to assess the effect of vitamin D supplementation on the same outcomes among the participants with low serum 25(OH)D levels.
Research design and methods
Participants were recruited from a population-based study (the Tromsø Study) based on their serum 25(OH)D measurements. A 3-h hyperglycemic clamp was performed, and the participants with low serum 25(OH)D levels were thereafter randomized to receive capsules of 20,000 IU vitamin D(3) or identical-looking placebo twice weekly for 6 months. A final hyperglycemic clamp was then performed.
Results
The 52 participants with high serum 25(OH)D levels (85.6 ± 13.5 nmol/L [mean ± SD]) had significantly higher insulin sensitivity index (ISI) and lower HbA(1c) and triglycerides (TGs) than the 108 participants with low serum 25(OH)D (40.3 ± 12.8 nmol/L), but the differences in ISI and TGs were not significant after adjustments. After supplementation, serum 25(OH)D was 142.7 ± 25.7 and 42.9 ± 17.3 nmol/L in 49 of 51 completing participants randomized to vitamin D and 45 of 53 randomized to placebo, respectively. At the end of the study, there were no statistically significant differences in the outcome variables between the two groups.
Conclusions
Vitamin D supplementation to apparently healthy subjects with insufficient serum 25(OH)D levels does not improve insulin sensitivity or secretion or serum lipid profile.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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