Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation
Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey JV, Bachmann V, Landolt HP
British journal of pharmacology · 76 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gobierno
- Swiss National Science Foundation
- Subvenciones
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (107874)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-09-28 · Br J Pharmacol · vol. 165 · número 6 · págs. 1904–1913
- Editorial
- Wiley
- Citado
- 119 citas · más que el 98% de estudios similares · 9.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Coffee research and impacts
- Palabras clave
- adenosine A2A receptor, single nucleotide polymorphisms, psychomotor vigilance, psychomotor vigilance task, sleep deprivation, caffeine, modafinil, slow-wave activity, sleep EEG, adenosine, sustained attention, genetic polymorphism
- MeSH
- humans, sleep deprivation, benzhydryl compounds, caffeine, receptor, adenosine a2a, central nervous system stimulants, electroencephalography, cross-over studies, double-blind method, psychomotor performance, attention, wakefulness, polymorphism, single nucleotide, adult, aged, middle aged, female, male, young adult, purinergic p1 receptor antagonists, modafinil
7 autores
- Sereina Bodenmann🇩🇪🇨🇭Goethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
- Christa Hohoff🇩🇪🇨🇭Goethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
- Christine Margarete Freitag🇩🇪🇨🇭Goethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
- Jürgen Deckert🇩🇪🇨🇭Goethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
- Julia Rétey🇩🇪🇨🇭Goethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
- V Bachmann🇩🇪🇨🇭Goethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
- Hans‐Peter Landolt🇩🇪🇨🇭 · autor de correspondenciaGoethe University Frankfurt; University of Zurich; University of Münster; University of Würzburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and purpose
Prolonged wakefulness impairs sustained vigilant attention, measured with the psychomotor vigilance task (PVT), and induces a compensatory increase in sleep intensity in recovery sleep, quantified by slow-wave activity (SWA) in the sleep electroencephalogram (EEG). These effects of sleep deprivation are counteracted by the adenosine receptor antagonist caffeine, implying involvement of the adenosine neuromodulator/receptor system. To examine a role for adenosine A(2A) receptors, we investigated whether variation of the A(2A) receptor gene (ADORA2A) modified effects of caffeine on PVT and SWA after sleep deprivation.
Experimental approach
A haplotype analysis of eight single-nucleotide polymorphisms of ADORA2A was performed in 82 volunteers. In 45 young men carrying five different allele combinations, we investigated the effects of prolonged waking and 2 × 200 mg caffeine or 2 × 100 mg modafinil on psychomotor vigilance, sleepiness, and the waking and sleep EEG.
Key results
Throughout extended wakefulness, the carriers of haplotype HT4 performed faster on the PVT than carriers of non-HT4 haplotype alleles. In haplotype HT4, caffeine failed to counteract the waking-induced impairment of PVT performance and the rebound of SWA in recovery sleep. However, caffeine was effective in non-HT4 allele carriers, and modafinil reduced the consequences of prolonged waking, independently of ADORA2A haplotype.
Conclusions and implications
Common genetic variation of ADORA2A is an important determinant of psychomotor vigilance in rested and sleep-deprived state. It also modulates individual responses to caffeine after sleep deprivation. These findings demonstrate a role for adenosine A(2A) receptors in the effects of prolonged wakefulness on vigilant attention and the sleep EEG.
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