Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial
Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 102 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-09-28 · J Bone Miner Res · vol. 27 · número 1 · págs. 170–176
- Editorial
- Oxford University Press
- Citado
- 150 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D3, vitamin D supplementation, falls, postmenopausal women, older women, muscle strength, mobility (physical function), Timed Up and Go test, 25-hydroxyvitamin D, calcium intake, fracture prevention, medication adherence
- MeSH
- humans, calcium, cholecalciferol, vitamin d, administration, oral, drug administration schedule, life style, accidental falls, postmenopause, movement, dietary supplements, aged, female, muscle strength
6 autores
- Paul Glendenning🇦🇺The University of Western Australia; Royal Perth Hospital
- Kun Zhu🇦🇺 · autor de correspondenciaThe University of Western Australia; Sir Charles Gairdner Hospital
- Charles Anoopkumar Inderjeeth🇦🇺The University of Western Australia; North Metropolitan Health Service
- Peter A. Howat🇦🇺Curtin University
- Joshua Richard Lewis🇦🇺The University of Western Australia; Sir Charles Gairdner Hospital
- Richard Lewis Prince🇦🇺The University of Western Australia; Sir Charles Gairdner Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Daily vitamin D in addition to calcium supplementation reduces falls and fractures in older women. However, poor adherence to therapy is a common clinical problem. To examine the effects of supervised oral 3-monthly vitamin D therapy on falls, muscle strength, and mobility, we conducted a 9-month randomized, double-blind, placebo-controlled trial in 686 community-dwelling ambulant women aged over 70 years. Participants received either oral cholecalciferol 150,000 IU every 3 months (n = 353) or an identical placebo (n = 333). All participants were advised to increase dietary calcium intake. Falls data were collected 3-monthly. At baseline, 3, 6, and 9 months, muscle strength was measured by a handheld dynamometer and mobility by the Timed Up and Go (TUG) test. Serum 25 hydroxyvitamin D (25OHD) was measured in a subgroup of 40 subjects. Mean age at baseline was 76.7 ± 4.1 years. The average serum 25OHD value at baseline was 65.8 ± 22.7 nmol/L. By 3, 6, and 9 months after supplementation, 25OHD levels of the vitamin D group were approximately 15 nmol/L higher than the placebo group. Calcium intake did not change significantly between baseline (864 ± 412 mg/day) and 9 months (855 ± 357 mg/day). Faller rates in the two groups did not differ: vitamin D group, 102 of 353 (29%); placebo group, 89 of 333 (27%). At 9 months, compared to placebo or baseline, muscle strength, and TUG were not altered by vitamin D. In conclusion, oral cholecalciferol 150,000 IU therapy administered 3-monthly had neither beneficial nor adverse effects on falls or physical function. These data together with previous findings confirm that intermittent large doses of vitamin D are ineffective or have a deleterious effect on falls. Thus despite adherence issues with daily vitamin D replacement, an intermittent, high-dose vitamin D regimen cannot be supported as a strategy to reduce falls and fractures.
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