Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis
Bloch MH, Qawasmi A
Journal of the American Academy of Child and Adolescent Psychiatry · 233 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Mental Health
- Gobierno
- National Center for Research Resources
- Gobierno
- NIMH NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Mental Health (K23MH091240); National Institute of Mental Health (R25 MH077823); National Institute of Mental Health (1K23MH091240-01); National Center for Research Resources (UL1RR024139)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2011-08-15 · J Am Acad Child Adolesc Psychiatry · vol. 50 · número 10 · págs. 991–1000
- Editorial
- Elsevier BV
- Citado
- 417 citas · más que el 94% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Attention Deficit Hyperactivity Disorder · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, attention deficit hyperactivity disorder, children, eicosapentaenoic acid, dietary supplementation, ADHD symptom severity, cell membrane fluidity, phospholipid composition, non-pharmacological treatment
- MeSH
- humans, fatty acids, omega-3, eicosapentaenoic acid, attention deficit disorder with hyperactivity, child
2 autores
- Michael H. Bloch🇺🇸 · autor de correspondenciaYale University
- Ahmad Qawasmi🇵🇸🇺🇸Al-Quds University; Yale University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Several studies have demonstrated differences in omega-3 fatty acid composition in plasma and in erythrocyte membranes in patients with attention-deficit/hyperactivity disorder (ADHD) compared with unaffected controls. Omega-3 fatty acids have anti-inflammatory properties and can alter central nervous system cell membrane fluidity and phospholipid composition. Cell membrane fluidity can alter serotonin and dopamine neurotransmission. The goal of this meta-analysis was to examine the efficacy of omega-3 fatty acid supplementation in children with ADHD.
Method
PubMed was searched for randomized placebo-controlled trials examining omega-3 fatty acid supplementation in children with ADHD symptomatology. The primary outcome measurement was standardized mean difference in rating scales of ADHD severity. Secondary analyses were conducted to determine the effects of dosing of different omega-3 fatty acids in supplements.
Results
Ten trials involving 699 children were included in this meta-analysis. Omega-3 fatty acid supplementation demonstrated a small but significant effect in improving ADHD symptoms. Eicosapentaenoic acid dose within supplements was significantly correlated with supplement efficacy. No evidence of publication bias or heterogeneity between trials was found.
Conclusion
Omega-3 fatty acid supplementation, particularly with higher doses of eicosapentaenoic acid, was modestly effective in the treatment of ADHD. The relative efficacy of omega-3 fatty acid supplementation was modest compared with currently available pharmacotherapies for ADHD such as psychostimulants, atomoxetine, or α(2) agonists. However, given its relatively benign side-effect profile and evidence of modest efficacy, it may be reasonable to use omega-3 fatty supplementation to augment traditional pharmacologic interventions or for families who decline other psychopharmacologic options.
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