Isolated low levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease: an individual participant data meta-analysis of 23 studies in the Asia-Pacific region
Huxley RR, Barzi F, Lam TH, Czernichow S, Fang X, Welborn T, Shaw J, Ueshima H, Zimmet P, Jee SH, Patel JV, Caterson I, Perkovic V, Woodward M, Asia Pacific Cohort Studies Collaboration and the Obesity in Asia Collaboration
Circulation · 117 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (571281)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-10-11 · Circulation · vol. 124 · número 19 · págs. 2056–2064
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 144 citas · más que el 99% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Paraoxonase enzyme and polymorphisms
- Palabras clave
- coronary artery disease, stroke, dyslipidemia, Asian populations, lipid phenotypes, cardiovascular risk, prevalence, individual patient data meta-analysis, Asia-Pacific region, lipid metabolism disorders, cardiovascular hospitalization, cardiovascular risk factors
- MeSH
- humans, coronary disease, obesity, prevalence, risk factors, adult, aged, middle aged, india, australasia, female, male, dyslipidemias, cholesterol, hdl, asian people, asia, eastern
14 autores
- Rachel Huxley🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Federica Barzi🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Tai Hing Lam🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Sébastien Czernichow🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Xianghua Fang🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Timothy Alexander Welborn🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Jonathan E. Shaw🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Hirotsugu Ueshima🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Paul Zimmet🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Sun Ha Jee🇦🇺🇺🇸🇰🇷🇫🇷🇭🇰The University of Sydney; University of Minnesota; Yonsei University; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Jeetesh V. Patel🇦🇺🇺🇸🇫🇷🇬🇧🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; Sandwell & West Birmingham Hospitals NHS Trust; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Ian Douglas Caterson🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Vlado Perkovic🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
- Mark Woodward🇦🇺🇺🇸🇫🇷🇭🇰The University of Sydney; University of Minnesota; Université de Versailles Saint-Quentin-en-Yvelines; The George Institute for Global Health; Hôpital Ambroise-Paré; University of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations.
Methods and results
Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and <1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9-33.3) of Asians versus 27.0% (95% CI, 26.5-27.5) of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2-22.5) versus 14.5% (95% CI, 14.1-14.9), respectively (P<0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31-1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27-2.19] versus 1.63 [95% CI, 1.24-2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67-1.00] with isolated low HDL-C).
Conclusion
Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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