Financiado en parte por Pfizer
Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis
Hackam DG, Woodward M, Newby LK, Bhatt DL, Shao M, Smith EE, Donner A, Mamdani M, Douketis JD, Arima H, Chalmers J, MacMahon S, Tirschwell DL, Psaty BM, Bushnell CD, Aguilar MI, Capampangan DJ, Werring DJ, De Rango P, Viswanathan A, Danchin N, Cheng CL, Yang YH, Verdel BM, Lai MS, Kennedy J, Uchiyama S, Yamaguchi T, Ikeda Y, Mrkobrada M
Circulation · 142 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Pfizer
- Gobierno
- Canadian Institutes of Health Research
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-10-18 · Circulation · vol. 124 · número 20 · págs. 2233–2242
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 187 citas · más que el 97% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 90 trabajos
- Acceso
- De pago
- Áreas de investigación
- Intracerebral and Subarachnoid Hemorrhage Research · Lipoproteins and Cardiovascular Health · Acute Ischemic Stroke Management
- Palabras clave
- statins, intracerebral hemorrhage, hemorrhagic stroke risk, cholesterol-lowering therapy, drug safety
- MeSH
- animals, humans, cerebral hemorrhage, hydroxymethylglutaryl-coa reductase inhibitors, case-control studies, cohort studies, randomized controlled trials as topic
30 autores
- Daniel G. Hackam🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Mark Woodward🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- L. Kristin Newby🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Deepak L. Bhatt🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Mingyuan Shao🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Eric Edward Smith🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Allan Donner🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Muhammad Mamdani🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- James Demetrios Douketis🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center; McMaster University
- Hisatomi Arima🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- John Philip Chalmers🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Stephen W MacMahon🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- David Tirschwell🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Bruce M. Psaty🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Cheryl Bushnell🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Maria I. Aguilar🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Dan J. Capampangan🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- David John Werring🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Paola De Rango🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Anand Viswanathan🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Nicolas Danchin🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Ching‐Lan Cheng🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Yea‐Huei Kao Yang🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- B.M. Verdel🇨🇦🇺🇸🇦🇺🇳🇱Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; Utrecht University; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Mei‐Shu Lai🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- James Kennedy🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Shinichiro Uchiyama🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Takenori Yamaguchi🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Yasuo Ikeda🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
- Marko Mrkobrada🇨🇦🇺🇸🇦🇺Western University; Brigham and Women's Hospital; The University of Sydney; Cleveland Clinic; University of Calgary; VA Boston Healthcare System; The George Institute for Global Health; Duke Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A recent large, randomized trial suggested that statins may increase the risk of intracerebral hemorrhage. Accordingly, we systematically reviewed the association of statins with intracerebral hemorrhage in randomized and observational data.
Methods and results
We screened 17 electronic bibliographic databases to identify eligible studies and consulted with experts in the field. We used DerSimonian-Laird random-effects models to compute summary risk ratios with 95% confidence intervals. Randomized trials, cohort studies, and case-control studies were analyzed separately. Only adjusted risk estimates were used for pooling observational data. We included published and unpublished data from 23 randomized trials and 19 observational studies. The complete data set comprised 248 391 patients and 14 784 intracerebral hemorrhages. Statins were not associated with an increased risk of intracerebral hemorrhage in randomized trials (risk ratio, 1.10; 95% confidence interval, 0.86-1.41), cohort studies (risk ratio, 0.94; 95% confidence interval, 0.81-1.10), or case-control studies (risk ratio, 0.60; 95% confidence interval, 0.41-0.88). Substantial statistical heterogeneity was evident for the case-control studies (I(2)=66%, P=0.01), but not for the cohort studies (I(2)=0%, P=0.48) or randomized trials (I(2)=30%, P=0.09). Sensitivity analyses by study design features, patient characteristics, or magnitude of cholesterol lowering did not materially alter the results.
Conclusions
We found no evidence that statins were associated with intracerebral hemorrhage; if such a risk is present, its absolute magnitude is likely to be small and outweighed by the other cardiovascular benefits of these drugs.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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