Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients
Moazzami AA, Zhang JX, Kamal-Eldin A, Aman P, Hallmans G, Johansson JE, Andersson SO
The Journal of nutrition · 42 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
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- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Birmingham
- Gobierno
- Svenska Forskningsrådet Formas
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- Vetenskapsrådet
Según 3 financiadores declarados.
Publicación
- Publicado
- 2011-10-20 · J Nutr · vol. 141 · número 12 · págs. 2126–2132
- Editorial
- Elsevier BV
- Citado
- 66 citas · más que el 92% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Food composition and properties
- Palabras clave
- prostate cancer, whole grain rye, rye bran, dietary intervention, plasma metabolomics, 1H NMR metabolomics, homocysteine metabolism, beta-hydroxybutyrate, acetone, betaine, N,N-dimethylglycine, dimethyl sulfone, leptin, adiponectin, glucagon, energy metabolism, early-stage prostate cancer, white wheat
- MeSH
- humans, triticum, prostatic neoplasms, betaine, 3-hydroxybutyric acid, insulin, prostate-specific antigen, homocysteine, sarcosine, plant preparations, magnetic resonance spectroscopy, diet, multivariate analysis, cross-over studies, aged, aged, 80 and over, united states, male, metabolomics, metabolome, secale
7 autores
- Ali Ata Moazzami🇸🇪 · autor de correspondenciaSwedish University of Agricultural Sciences
- Jie‐Xian Zhang🇸🇪Umeå University
- Afaf Kamal‐Eldin🇸🇪Swedish University of Agricultural Sciences
- Per Åman🇸🇪Swedish University of Agricultural Sciences
- Göran Hallmans🇸🇪Umeå University
- Jan‐Erik Johansson🇸🇪Örebro University Hospital
- Sven-Olof Andersson🇸🇪Örebro University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Prostate cancer (PC) is the most common cancer in the Western world and the second most important cancer causing male deaths, after lung cancer, in the United States and Britain. Lifestyle and dietary changes are recommended for men diagnosed with early-stage PC. It has been shown that a diet rich in whole grain (WG) rye reduces the progression of early-stage PC, but the underlying mechanism is not clear. This study sought to identify changes in the metabolic signature of plasma in patients with early-stage PC following intervention with a diet rich in WG rye and rye bran product (RP) compared with refined white wheat product (WP) as a tool for mechanistic investigation of the beneficial health effects of RP on PC progression. Seventeen PC patients received 485 g RP or WP in a randomized, controlled, crossover design during a period of 6 wk with a 2-wk washout period. At the end of each intervention period, plasma was collected after fasting and used for (1)H NMR-based metabolomics. Multilevel partial least squares discriminant analysis was used for paired comparisons of multivariate data. A metabolomics analysis of plasma showed an increase in 5 metabolites, including 3-hydroxybutyric acid, acetone, betaine, N,N-dimethylglycine, and dimethyl sulfone, after RP. To understand these metabolic changes, fasting plasma homocysteine, leptin, adiponectin, and glucagon were measured separately. The plasma homocysteine concentration was lower (P = 0.017) and that of leptin tended to be lower (P = 0.07) after RP intake compared to WP intake. The increase in plasma 3-hydroxybutyric acid and acetone after RP suggests a shift in energy metabolism from anabolic to catabolic status, which could explain some of the beneficial health effects of WG rye, i.e., reduction in prostate-specific antigen and reduced 24-h insulin secretion. In addition, the increase in betaine and N,N-dimethylglycine and the decrease in homocysteine show a favorable shift in homocysteine metabolism after RP intake.
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