Effects of 1,3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women
Bloomer RJ, Harvey IC, Farney TM, Bell ZW, Canale RE
The Physician and sportsmedicine · 28 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-09-01 · Phys Sportsmed · vol. 39 · número 3 · págs. 111–120
- Editorial
- Taylor & Francis
- Citado
- 39 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Blood Pressure and Hypertension Studies · Pharmacology and Obesity Treatment
- Palabras clave
- caffeine, dietary supplements, heart rate, blood pressure, rate-pressure product, norepinephrine, epinephrine, dose-response relationship, acute ingestion, stimulants
- MeSH
- humans, geranium, caffeine, plant extracts, administration, oral, analysis of variance, cross-over studies, double-blind method, blood pressure, heart rate, adult, female, male
5 autores
- Richard J. Bloomer🇺🇸 · autor de correspondenciaUniversity of Memphis
- Innocence C. Harvey🇺🇸University of Memphis
- Tyler M. Farney🇺🇸University of Memphis
- Zach W. Bell🇺🇸University of Memphis
- Robert E. Canale🇺🇸University of Memphis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The use of 1,3-dimethylamylamine (geranamine), alone and in combination with caffeine, is becoming widespread within the dietary supplement industry. To our knowledge, no data are available concerning the effects of oral geranamine intake on heart rate (HR) and blood pressure in individuals.
Methods
Ten young healthy men and women ingested 1 of 5 conditions on different days using a double-blind, randomized, crossover design. The following were ingested after a 10-hour overnight fast: 250 mg caffeine (C), 50 mg geranamine (G 50 mg), 75 mg geranamine (G 75 mg), 250 mg caffeine + 50 mg geranamine (C + G 50 mg), and 250 mg caffeine + 75 mg geranamine (C + G 75 mg). Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and rate pressure product (RPP) were measured pre-ingestion and at 30, 60, 90, and 120 minutes post-ingestion. Plasma norepinephrine (NE) and epinephrine (EPI) were measured pre-ingestion and at 60 and 120 minutes post-ingestion.
Results
Heart rate was unaffected by treatment, but blood pressure and RPP were higher with geranamine, generally in a dose-dependent manner. The peak percent change from pre-ingestion in SBP (~20%), DBP (~17%), and RPP (~9%) was noted with C + G 75 mg at 60 minutes post-ingestion. Plasma NE and EPI were relatively unaffected by treatment.
Conclusion
We report for the first time that acute ingestion of 1,3-dimethylamylamine alone and in combination with caffeine results in an increase in SBP, DBP, and RPP without an increase in HR. The largest increase is observed at 60 minutes post-ingestion of C + G 75 mg. These changes cannot be explained by circulating NE and EPI.
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