Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS
Carcinogenesis · 102 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA93780); National Institute of Environmental Health Sciences (P30 ES 003819); National Institute of Environmental Health Sciences (P01 ES006052)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2011-11-01 · Carcinogenesis · vol. 33 · número 1 · págs. 101–107
- Editorial
- Oxford University Press
- Citado
- 130 citas · más que el 94% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Free Radicals and Antioxidants · Tryptophan and brain disorders
- Palabras clave
- Sulforaphane, Glucoraphanin, Cruciferous vegetables, Glucosinolate, Mercapturic acid, Food science, Excretion, Chemistry, Glutathione, Brassica, Crossover study, Toxicology, Medicine, Biochemistry, Botany, Internal medicine, Biology
- MeSH
- humans, brassica, aldehydes, acrolein, oximes, thiocyanates, ethylene oxide, benzene, imidoesters, isothiocyanates, sulfoxides, glucosinolates, acetylcysteine, dna adducts, air pollutants, smoking, beverages, adult, middle aged, china, female, male, biomarkers, polycyclic aromatic hydrocarbons
15 autores
- Thomas W. Kensler🇺🇸 · autor de correspondenciaJohns Hopkins University; University of Pittsburgh; Johns Hopkins Medicine
- Derek K. Ng🇺🇸Johns Hopkins University
- Steven G. Carmella🇺🇸University of Minnesota Medical Center
- Menglan Chen🇺🇸University of Minnesota Medical Center
- Lisa P. Jacobson🇺🇸Johns Hopkins University
- Álvaro Muñoz🇺🇸Johns Hopkins University
- Patricia A. Egner🇺🇸Johns Hopkins University
- Jianguo Chen🇨🇳Qidong Liver Cancer Prevention Research
- Geng Qian🇨🇳Qidong Liver Cancer Prevention Research
- Tao Yang Chen🇨🇳Qidong Liver Cancer Prevention Research
- Jed W. Fahey🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Paul Talalay🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- John D. Groopman🇺🇸Johns Hopkins University
- Jian‐Min Yuan🇺🇸University of Minnesota Medical Center
- Stephen S. Hecht🇺🇸University of Minnesota Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases. Two broccoli sprout-derived beverages, one sulforaphane-rich (SFR) and the other glucoraphanin-rich (GRR), were evaluated for pharmacodynamic action in a crossover clinical trial design. Study participants were recruited from the farming community of He Zuo Township, Qidong, China, previously documented to have a high incidence of hepatocellular carcinoma with concomitant exposures to aflatoxin and more recently characterized with exposures to substantive levels of airborne pollutants. Fifty healthy participants were randomized into two treatment arms. The study protocol was as follows: a 5 days run-in period, a 7 days administration of beverage, a 5 days washout period and a 7 days administration of the opposite beverage. Urinary excretion of the mercapturic acids of acrolein, crotonaldehyde, ethylene oxide and benzene were measured both pre- and postinterventions using liquid chromatography tandem mass spectrometry. Statistically significant increases of 20-50% in the levels of excretion of glutathione-derived conjugates of acrolein, crotonaldehyde and benzene were seen in individuals receiving SFR, GRR or both compared with their preintervention baseline values. No significant differences were seen between the effects of SFR versus GRR. Intervention with broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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