Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals
Tholstrup T, Hjerpsted J, Raff M
The American journal of clinical nutrition · 46 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-11-10 · Am J Clin Nutr · vol. 94 · número 6 · págs. 1426–1432
- Editorial
- Elsevier BV
- Citado
- 80 citas · más que el 96% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Cholesterol and Lipid Metabolism
- Palabras clave
- palm olein, olive oil, lard, palmitic acid, serum cholesterol, LDL cholesterol, total cholesterol, HDL cholesterol, triglycerides, C-reactive protein, insulin, glucose, dietary fat, healthy men
- MeSH
- humans, arecaceae, cholesterol, dietary fats, oleic acid, triglycerides, plant oils, diet, cross-over studies, double-blind method, adult, male, cholesterol, ldl, young adult, olive oil, palm oil
3 autores
- Tine Tholstrup🇩🇰University of Copenhagen
- Julie Hjerpsted
- Marianne Raff
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Despite the high content of palmitic acid, palm olein has been shown to have a neutral effect on plasma cholesterol concentrations when compared with olive oil, which is suggested to be attributable to palmitic acid in the sn-1 and sn-3 position. In contrast, palmitic acid is in the sn-2 position in lard.
Objective
The objective was to investigate the effects of a diet rich in palm olein, fractionated palm oil, olive oil, and lard on plasma blood lipids, inflammatory markers, glucose, and insulin.
Design
A controlled double-blinded, randomized 3 × 3 wk crossover dietary intervention study included 32 healthy men who daily replaced part of their habitual dietary fat intake with ~ 17% of energy from palm olein, olive oil, or lard, respectively.
Results
Compared with intake of olive oil, palm olein and lard increased total cholesterol and LDL cholesterol (P < 0.0001). Palm olein resulted in a lower plasma triacylglycerol concentration than did olive oil (P < 0.01). No difference in effects was observed in plasma HDL-cholesterol, high-sensitivity C-reactive protein, plasminogen activator-1, insulin, and glucose concentrations.
Conclusions
The current study did not support the previous finding that the effect of palm olein on total plasma cholesterol and LDL cholesterol in healthy individuals with normal plasma cholesterol concentrations is neutral compared with that of olive oil. Thus, sn-positioning was not confirmed to be important with regard to the effect on plasma cholesterol. The relatively lower plasma triacylglycerol concentration after the palm olein diet than after the olive oil diet was unexpected. This trial is registered at clinicaltrials.gov as NCT00743301.
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