Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial
Dean AJ, Bellgrove MA, Hall T, Phan WM, Eyles DW, Kvaskoff D, McGrath JJ
PloS one · 133 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Queensland Health
Según 1 financiador declarado.
Publicación
- Publicado
- 2011-11-04 · PLoS One · vol. 6 · número 11 · pág. e25966
- Editorial
- Public Library of Science
- Citado
- 180 citas · más que el 99% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Schizophrenia research and treatment
- Palabras clave
- vitamin D supplementation, vitamin D3, cognitive function, emotional functioning, working memory, response inhibition, cognitive flexibility, hallucination proneness, psychotic-like experiences, depression, anxiety, anger, young adults, vitamin D status
- MeSH
- humans, vitamin d, emotions, cognition, dietary supplements, adult, female, male
7 autores
- Angela J. Dean🇦🇺 · autor de correspondenciaThe University of Queensland
- Mark A. Bellgrove🇦🇺The University of Queensland
- Teresa Hall🇦🇺The University of Queensland
- Wei Ming Jonathan Phan🇦🇺The University of Queensland
- Darryl Walter Eyles🇦🇺The University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
- David Kvaskoff🇦🇺The University of Queensland
- John Joseph McGrath🇦🇺The University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo.
Methods/principal findings
Healthy young adults were recruited to a parallel-arm, double-blind trial conducted at The University of Queensland. Participants were randomly allocated to receive Vitamin D (one capsule daily, containing 5000 IU cholecalciferol) or identical placebo capsule for six weeks. All participants and outcome assessors were blinded to group assignment. Primary outcome measures assessed at baseline and 6 weeks were working memory, response inhibition and cognitive flexibility. Secondary outcomes were: hallucination-proneness, psychotic-like experiences, and ratings of depression, anxiety and anger. 128 participants were recruited, randomised and included in primary analyses (vitamin D n = 63; placebo n = 65). Despite significant increases in vitamin D status in the active group, no significant changes were observed in working memory (F = 1.09; p = 0.30), response inhibition (F = 0.82; p = 0.37), cognitive flexibility (F = 1.37; p = 0.24) or secondary outcomes. No serious adverse effects were reported.
Conclusions
Our findings indicate that vitamin D supplementation does not influence cognitive or emotional functioning in healthy young adults. Future controlled trials in targeted populations of interest are required to determine whether supplementation can improve functioning in these domains. Australian and New Zealand Clinical Trials Registry; ACTRN12610000318088.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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