Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study
Aronis KN, Vamvini MT, Chamberland JP, Sweeney LL, Brennan AM, Magkos F, Mantzoros CS
Metabolism: clinical and experimental · 47 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-081913); National Institute of Diabetes and Digestive and Kidney Diseases (K24DK081913); National Center for Research Resources (M01-RR-01032-328840); National Center for Research Resources (M01RR001032)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2011-11-10 · Metabolism · vol. 61 · número 4 · págs. 577–582
- Editorial
- Elsevier BV
- Citado
- 60 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nuts composition and effects · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- walnut consumption, adiponectin, apolipoprotein(a), metabolic syndrome, obesity, inflammatory markers, endothelial function, lipid profile, short-term dietary intervention, cardiovascular risk
- MeSH
- humans, juglans, obesity, tumor necrosis factor-alpha, c-reactive protein, serum amyloid a protein, apolipoprotein a-i, cell adhesion molecules, selectins, vascular cell adhesion molecule-1, thrombomodulin, interleukins, statistics, nonparametric, cross-over studies, double-blind method, middle aged, female, male, adiponectin, resistin, alpha-2-hs-glycoprotein, metabolic syndrome
7 autores
- Konstantinos N. Aronis🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Maria T. Vamvini🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- John P. Chamberland🇺🇸Beth Israel Deaconess Medical Center; Harvard University; VA Boston Healthcare System
- Laura L. Sweeney🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Aoife M. Brennan🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Faidon Magkos🇺🇸🇬🇷Beth Israel Deaconess Medical Center; Harvard University; Harokopio University of Athens
- Christos Socrates Mantzoros🇺🇸Beth Israel Deaconess Medical Center; Harvard University; VA Boston Healthcare System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.