Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running
McAnulty LS, Nieman DC, Dumke CL, Shooter LA, Henson DA, Utter AC, Milne G, McAnulty SR
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 93 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Resultado principal
- Solo mecanismos
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-12-01 · Appl Physiol Nutr Metab · vol. 36 · número 6 · págs. 976–984
- Editorial
- NRC Research Press
- Citado
- 142 citas · más que el 96% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Exercise and Physiological Responses · Antioxidant Activity and Oxidative Stress · Vitamin C and Antioxidants Research
- Palabras clave
- Oxidative stress, Inflammation, Urine, Antioxidant, Immune system, Endocrinology, Ingestion, Internal medicine, Ferric reducing ability of plasma, Natural killer cell, Medicine, Chemistry, Immunology, Biochemistry, Antioxidant capacity, Cytotoxic T cell
- MeSH
- killer cells, natural, humans, fruit, myositis, f2-isoprostanes, thymidine, anti-inflammatory agents, non-steroidal, interleukin-10, antioxidants, lymphocyte count, exercise, oxidative stress, physical endurance, running, adolescent, adult, young adult, athletes, biomarkers, blueberry plants
8 autores
- Lisa S. McAnulty🇺🇸Appalachian State University
- David Christopher Nieman🇺🇸Appalachian State University
- Charles L. Dumke🇺🇸University of Montana
- Lesli Shooter🇺🇸Appalachian State University
- Dru Anne Henson🇺🇸Appalachian State University
- Alan C. Utter🇺🇸Appalachian State University
- Ginger L. Milne🇺🇸Vanderbilt University
- Steven R. McAnulty🇺🇸Appalachian State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberries are rich in antioxidants known as anthocyanins, which may exhibit significant health benefits. Strenous exercise is known to acutely generate oxidative stress and an inflammatory state, and serves as an on-demand model to test antioxidant and anti-inflammatory compounds. The purpose of this study was to examine whether 250 g of blueberries per day for 6 weeks and 375 g given 1 h prior to 2.5 h of running at ∼72% maximal oxygen consumption counters oxidative stress, inflammation, and immune changes. Twenty-five well-trained subjects were recruited and randomized into blueberry (BB) (N = 13) or control (CON) (N = 12) groups. Blood, muscle, and urine samples were obtained pre-exercise and immediately postexercise, and blood and urine 1 h postexercise. Blood was examined for F₂-isoprostanes for oxidative stress, cortisol, cytokines, homocysteine, leukocytes, T-cell function, natural killer (NK), and lymphocyte cell counts for inflammation and immune system activation, and ferric reducing ability of plasma for antioxidant capacity. Muscle biopsies were examined for glycogen and NFkB expression to evaluate stress and inflammation. Urine was tested for modification of DNA (8-OHDG) and RNA (5-OHMU) as markers of nucleic acid oxidation. A 2 (treatment) × 3 (time) repeated measures ANOVA was used for statistical analysis. Increases in F₂-isoprostanes and 5-OHMU were significantly less in BB and plasma IL-10 and NK cell counts were significantly greater in BB vs. CON. Changes in all other markers did not differ. This study indicates that daily blueberry consumption for 6 weeks increases NK cell counts, and acute ingestion reduces oxidative stress and increases anti-inflammatory cytokines.
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