Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial
Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Gharavi A, Kalayi A, Shariatzadeh N, Zahedirad M, Khalaji N, Haidari H
BMC medicine · 109 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Foundation
- Gobierno
- Iran National Science Foundation
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Universidad u hospital
- National Nutrition and Food Technology Research Institute
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2011-11-24 · BMC Med · vol. 9 · número 1 · pág. 125
- Editorial
- BioMed Central
- Citado
- 150 citas · más que el 98% de estudios similares · 7.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nitric Oxide and Endothelin Effects · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- vitamin D, doogh, yogurt drink, type 2 diabetes, endothelial dysfunction, endothelin-1, E-selectin, MMP-9, glycemic control, lipid profile, diabetic vascular disease, cardiovascular risk, food fortification, fat mass, QUICKI, HbA1c, triglycerides, HDL cholesterol, waist circumference
- MeSH
- humans, diabetes mellitus, type 2, cholecalciferol, endothelin-1, e-selectin, body mass index, double-blind method, blood pressure, yogurt, food, fortified, adult, aged, middle aged, female, male, matrix metalloproteinase 9, biomarkers
11 autores
- Sakineh Shab‐Bidar🇮🇷Tehran University of Medical Sciences
- Tirang Reza Neyestani🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Abolghassem Djazayery🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- M R Eshraghian🇮🇷Tehran University of Medical Sciences
- Anahita Houshiarrad🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- A’azam Gharavi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Ali Kalayi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Nastaran Shariátzadeh🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Malihe Zahedirad🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Niloufar Khalaji🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Homa Haidari🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Endothelial dysfunction has been proposed as the underlying cause of diabetic angiopathy that eventually leads to cardiovascular disease, the major cause of death in diabetes. We recently demonstrated the ameliorating effect of regular vitamin D intake on the glycemic status of patients with type 2 diabetes (T2D). In this study, the effects of improvement of vitamin D status on glycemic status, lipid profile and endothelial biomarkers in T2D subjects were investigated.
Methods
Subjects with T2D were randomly allocated to one of the two groups to receive either plain yogurt drink (PYD; containing 170 mg calcium and no vitamin D/250 mL, n1 = 50) or vitamin D3-fortified yogurt drink (FYD; containing 170 mg calcium and 500 IU/250 mL, n2 = 50) twice a day for 12 weeks. Anthropometric measures, glycemic status, lipid profile, body fat mass (FM) and endothelial biomarkers including serum endothelin-1, E-selectin and matrix metalloproteinase (MMP)-9 were evaluated at the beginning and after the 12-week intervention period.
Results
The intervention resulted in a significant improvement in fasting glucose, the Quantitative Insulin Check Index (QUICKI), glycated hemoglobin (HbA1c), triacylglycerols, high-density lipoprotein cholesterol (HDL-C), endothelin-1, E-selectin and MMP-9 in FYD compared to PYD (P < 0.05, for all). Interestingly, difference in changes of endothelin-1, E-selectin and MMP-9 concentrations in FYD compared to PYD (-0.35 ± 0.63 versus -0.03 ± 0.55, P = 0.028; -3.8 ± 7.3 versus 0.95 ± 8.3, P = 0.003 and -2.3 ± 3.7 versus 0.44 ± 7.1 ng/mL, respectively, P < 0.05 for all), even after controlling for changes of QUICKI, FM and waist circumference, remained significant for endothelin-1 and MMP-9 (P = 0.009 and P = 0.005, respectively) but disappeared for E-selectin (P = 0.092). On the contrary, after controlling for serum 25(OH)D, the differences disappeared for endothelin-1(P = 0.066) and MMP-9 (P = 0.277) but still remained significant for E-selectin (P = 0.011).
Conclusions
Ameliorated vitamin D status was accompanied by improved glycemic status, lipid profile and endothelial biomarkers in T2D subjects. Our findings suggest both direct and indirect ameliorating effects of vitamin D on the endothelial biomarkers.
Trial registration
ClinicalTrials.gov: NCT01236846.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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