Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults
Rosenblum JL, Castro VM, Moore CE, Kaplan LM
The American journal of clinical nutrition · 96 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK046200)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-12-15 · Am J Clin Nutr · vol. 95 · número 1 · págs. 101–108
- Editorial
- Elsevier BV
- Citado
- 158 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Nutrition and Health Studies
- Palabras clave
- calcium supplementation, vitamin D supplementation, orange juice, visceral adipose tissue, abdominal fat, obesity, overweight, weight loss, subcutaneous adipose tissue, dietary fat
- MeSH
- humans, citrus, obesity, weight loss, calcium, dietary, calcium, micronutrients, vitamin d, tomography, x-ray computed, double-blind method, energy intake, beverages, dietary supplements, food, fortified, adult, middle aged, female, male, intra-abdominal fat, overweight
4 autores
- Jennifer Rosenblum🇺🇸Massachusetts General Hospital
- Victor Manuel Castro🇺🇸Massachusetts General Hospital
- Carolyn E. Moore🇺🇸Massachusetts General Hospital
- Lee M. Kaplan🇺🇸Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Several studies suggest that calcium and vitamin D (CaD) may play a role in the regulation of abdominal fat mass.
Objective
This study investigated the effect of CaD-supplemented orange juice (OJ) on weight loss and reduction of visceral adipose tissue (VAT) in overweight and obese adults (mean ± SD age: 40.0 ± 12.9 y).
Design
Two parallel, double-blind, placebo-controlled trials were conducted with either regular or reduced-energy (lite) orange juice. For each 16-wk trial, 171 participants were randomly assigned to 1 of 2 groups. The treatment groups consumed three 240-mL glasses of OJ (regular or lite) fortified with 350 mg Ca and 100 IU vitamin D per serving, and the control groups consumed either unfortified regular or lite OJ. Computed tomography scans of VAT and subcutaneous adipose tissue were performed by imaging a single cut at the lumbar 4 level.
Results
After 16 wk, the average weight loss (∼2.45 kg) did not differ significantly between groups. In the regular OJ trial, the reduction of VAT was significantly greater (P = 0.024) in the CaD group (-12.7 ± 25.0 cm(2)) than in the control group (-1.3 ± 13.6 cm(2)). In the lite OJ trial, the reduction of VAT was significantly greater (P = 0.039) in the CaD group (-13.1 ± 18.4 cm(2)) than in the control group (-6.4 ± 17.5 cm(2)) after control for baseline VAT. The effect of calcium and vitamin D on VAT remained highly significant when the results of the 2 trials were combined (P = 0.007).
Conclusions
The findings suggest that calcium and/or vitamin D supplementation contributes to a beneficial reduction of VAT. This trial is registered at clinicaltrial.gov as NCT00386672, NCT01363115.
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