Genetic determinants of blood pressure responses to caffeine drinking
Renda G, Zimarino M, Antonucci I, Tatasciore A, Ruggieri B, Bucciarelli T, Prontera T, Stuppia L, De Caterina R
The American journal of clinical nutrition · 42 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-12-15 · Am J Clin Nutr · vol. 95 · número 1 · págs. 241–248
- Editorial
- Elsevier BV
- Citado
- 69 citas · más que el 84% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Blood Pressure and Hypertension Studies · Genetic Associations and Epidemiology
- Palabras clave
- caffeine, blood pressure response, coffee consumption, genetic polymorphism, adenosine A2A receptor, ADRA2B, alpha2-adrenoceptors, caffeine metabolism, catecholamines, epinephrine, ambulatory blood pressure monitoring
- MeSH
- humans, epinephrine, caffeine, receptors, adrenergic, alpha-2, receptor, adenosine a2a, adenosine, plant extracts, blood pressure monitoring, ambulatory, double-blind method, blood pressure, polymorphism, genetic, coffee, adult, male, young adult
9 autores
- Giulia Renda🇮🇹University of Chieti-Pescara
- Marco Zimarino🇮🇹University of Chieti-Pescara
- Ivana Antonucci🇮🇹University of Chieti-Pescara
- Alfonso Tatasciore🇮🇹University of Chieti-Pescara
- Benedetta Ruggieri🇮🇹University of Chieti-Pescara
- Tonino Bucciarelli🇮🇹University of Chieti-Pescara
- Tina Prontera🇮🇹University of Chieti-Pescara
- Liborio Stuppia🇮🇹University of Chieti-Pescara
- Raffaele De Caterina🇮🇹University of Chieti-Pescara
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The widely observed between-subject variability in cardiovascular responses to coffee may have a genetic basis.
Objective
We evaluated acute blood pressure (BP) responses to caffeine and explored whether they are influenced by candidate gene variants affecting caffeine metabolism (for cytochrome P450 1A2), adenosine metabolism (for adenosine receptor and AMP deaminase), or catecholamine receptors.
Methods
We recruited 110 healthy male habitual moderate coffee drinkers who refrained from drinking coffee on the day preceding the study. Each subject underwent ambulatory BP monitoring at 6-min intervals for 2 h. Each participant was administered, in a double-blind design, 40 mL of either a decaffeinated coffee preparation plus 3 mg caffeine/kg (caf) or the corresponding vehicle (decaf). The protocol was repeated 24 h later with the alternative preparation. Blood samples were collected for genetic and plasma caffeine and catecholamine evaluations.
Results
Compared with decaf, caf was associated with a mean (± SD) significant increase in systolic BP of 4 ± 12 mm Hg and in diastolic BP of 3 ± 10 mm Hg (P < 0.001 for both). Plasma caffeine and adrenaline increased after caf, but not after decaf. Of 11 gene polymorphisms analyzed, a relation was observed between the ADORA2A TT variant and the change in SBP peak and between the ADRA2B I variant and the changes in both SBP mean and peak; mean peak change in SBP; these variants were associated with increased SBP responses to caf.
Conclusions
Variability in the acute BP response to coffee may be partly explained by genetic polymorphisms of the adenosine A2A receptors and α(2)-adrenergic receptors. This trial is registered at clinicaltrials.gov as NCT01330680.
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