Financiado en parte por Nestec
Plasma alkylresorcinols as a biomarker of whole-grain food consumption in a large population: results from the WHOLEheart Intervention Study
Ross AB, Bourgeois A, Macharia HN, Kochhar S, Jebb SA, Brownlee IA, Seal CJ
The American journal of clinical nutrition · 71 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nestec
- Gobierno
- Medical Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-12-15 · Am J Clin Nutr · vol. 95 · número 1 · págs. 204–211
- Editorial
- Elsevier BV
- Citado
- 103 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Phytochemicals and Antioxidant Activities
- Palabras clave
- alkylresorcinols, whole grain intake, dietary biomarkers, wheat, rye, dietary intervention, plasma triglycerides, free fatty acids, sex differences, overweight and obesity
- MeSH
- humans, triticum, obesity, resorcinols, fatty acids, nonesterified, triglycerides, diet, sex factors, energy intake, phenotype, self report, biomarkers, edible grain, secale
7 autores
- Alastair B. Ross🇨🇭Nestlé (Switzerland)
- Alexandre Bourgeois🇨🇭Nestlé (Switzerland)
- Harrison Ndung’u Macharia🇨🇭Nestlé (Switzerland)
- Sunil Kochhar🇨🇭Nestlé (Switzerland)
- Susan Ann Jebb🇬🇧Medical Research Council
- Iain A. Brownlee🇨🇭🇬🇧Nestlé (Switzerland); Newcastle University
- Chris J. Seal🇨🇭🇬🇧Nestlé (Switzerland); Newcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Small-scale, short-term intervention studies have suggested that plasma alkylresorcinol (AR) concentrations may be biomarkers of whole grain (WG) wheat and rye intakes.
Objective
The objective was to determine whether plasma AR concentrations reflect self-reported WG food intake in a 16-wk WG intervention study and to establish which phenotypic characteristics influence plasma AR concentrations.
Design
In a randomized parallel-group dietary intervention study, 316 overweight and obese participants with a WG intake of <30 g/d were recruited and randomly assigned to 1 of 3 groups: control (no dietary change), intervention 1 (60 g WG/d for 16 wk), or intervention 2 (60 g WG/d for 8 wk followed by 120 g WG/d for 8 wk). Fasting blood samples were collected at baseline, 8 wk, and 16 wk for the measurement of plasma lipids and ARs.
Results
Plasma samples from 266 study completers were analyzed. Total plasma AR concentrations increased with the WG intervention and could be used to distinguish between control subjects and those who consumed 60 or 120 g WG, but not between those who consumed 60 and 120 g WG. Plasma AR concentrations were higher in men, were positively associated with plasma triglyceride concentrations, and were negatively associated with nonesterified fatty acids.
Conclusions
Plasma AR concentrations were correlated with WG intake and could be used to distinguish between low- and high-WG consumers. Sex and plasma lipid concentrations independently influenced plasma AR concentrations, although plasma triglycerides may explain higher concentrations in men. This trial is registered as ISRCT no. 83078872.
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