Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis
Muir SW, Montero-Odasso M
Journal of the American Geriatrics Society · 326 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
Según 1 financiador declarado.
Publicación
- Publicado
- 2011-12-01 · J Am Geriatr Soc · vol. 59 · número 12 · págs. 2291–2300
- Editorial
- Wiley
- Citado
- 470 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Nutrition and Health in Aging
- Palabras clave
- vitamin D supplementation, older adults, muscle strength, gait, balance, postural sway, Timed Up and Go test, lower limb strength, dosing frequency
- MeSH
- humans, vitamin d, gait, dietary supplements, aged, middle aged, muscle strength, postural balance
2 autores
- Susan W. Muir🇨🇦Western University
- Manuel Montero‐Odasso🇨🇦 · autor de correspondenciaWestern University; Lawson Health Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To systematically review and quantitatively synthesize the effect of vitamin D supplementation on muscle strength, gait, and balance in older adults.
Design
Systematic review and meta-analysis.
Setting
MEDLINE, EMBASE, Cochrane Library, bibliographies of selected articles, and previous systematic reviews were searched between January 1980 and November 2010 for eligible articles.
Participants
Older adults (≥60) participating in randomized controlled trials of the effect of supplemental vitamin D without an exercise intervention on muscle strength, gait, and balance.
Measurements
Data were independently extracted, and study quality was evaluated. Meta-analysis using a fixed-effects model was performed and the I(2) statistic was used to assess heterogeneity.
Results
Of 714 potentially relevant articles, 13 met the inclusion criteria. In the pooled analysis, vitamin D supplementation yielded a standardized mean difference of -0.20 (95% confidence interval (CI) = -0.39 to -0.01, P = .04, I(2) = 0%) for reduced postural sway, -0.19 (95% CI = -0.35 to -0.02, P = .03, I(2) = 0%) for decreased time to complete the Timed Up and Go Test, and 0.05 (95% CI = -0.11 to 0.20, P = .04, I(2) = 0%) for lower extremity strength gain. Regarding dosing frequency regimen, only one study demonstrated a beneficial effect on balance with a single large dose. All studies with daily doses of 800 IU or more demonstrated beneficial effects on balance and muscle strength.
Conclusion
Supplemental vitamin D with daily doses of 800 to 1,000 IU consistently demonstrated beneficial effects on strength and balance. An effect on gait was not demonstrated, although further evaluation is recommended.
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