Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies
Larsson SC, Orsini N, Wolk A
The American journal of clinical nutrition · 122 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Universidad u hospital
- Karolinska Institutet
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-12-28 · Am J Clin Nutr · vol. 95 · número 2 · págs. 362–366
- Editorial
- Elsevier BV
- Citado
- 188 citas · más que el 77% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, stroke risk, ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, dose-response relationship, stroke prevention
- MeSH
- humans, brain ischemia, cerebral hemorrhage, subarachnoid hemorrhage, magnesium, trace elements, risk factors, prospective studies, dose-response relationship, drug, stroke
3 autores
- Susanna C. Larsson🇸🇪Karolinska Institutet
- Nicola Orsini🇸🇪Karolinska Institutet
- Alicja Wolk🇸🇪Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results.
Objective
We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk.
Design
Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model.
Results
Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, I(2) = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14).
Conclusion
Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke.
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