High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial
Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, Decallonne B, Bouillon R, Decramer M, Janssens W
Annals of internal medicine · 259 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-01-17 · Ann Intern Med · vol. 156 · número 2 · págs. 105–114
- Editorial
- American College of Physicians
- Citado
- 363 citas · más que el 100% de estudios similares · 30.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Chronic Obstructive Pulmonary Disease (COPD) Research · Asthma and respiratory diseases
- Palabras clave
- chronic obstructive pulmonary disease, vitamin D supplementation, high-dose vitamin D, COPD exacerbations, 25-hydroxyvitamin D, vitamin D deficiency, time to first exacerbation, hospitalization, FEV1, quality of life, mortality, airway inflammation, osteoporosis prevention
- MeSH
- sputum, humans, osteoporosis, pulmonary disease, chronic obstructive, recurrence, vitamin d, antimicrobial cationic peptides, forced expiratory volume, treatment outcome, cause of death, double-blind method, phagocytosis, quality of life, dietary supplements, aged, middle aged, female, male, cathelicidins
10 autores
- An Lehouck🇧🇪Universitair Ziekenhuis Leuven
- Chantal Mathieu🇧🇪Universitair Ziekenhuis Leuven
- Claudia Carremans🇧🇪Universitair Ziekenhuis Leuven
- Femke Baeke🇧🇪Universitair Ziekenhuis Leuven
- Jan Verhaegen🇧🇪Universitair Ziekenhuis Leuven
- Johan Van Eldere🇧🇪Universitair Ziekenhuis Leuven
- Brigitte Decallonne🇧🇪Universitair Ziekenhuis Leuven
- Roger Bouillon🇧🇪Universitair Ziekenhuis Leuven
- Marc Decramer🇧🇪Universitair Ziekenhuis Leuven
- Wim Janssens🇧🇪Universitair Ziekenhuis Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low serum 25-hydroxyvitamin D (25-[OH]D) levels have been associated with lower FEV(1), impaired immunologic control, and increased airway inflammation. Because many patients with chronic obstructive pulmonary disease (COPD) have vitamin D deficiency, effects of vitamin D supplementation may extend beyond preventing osteoporosis.
Objective
To explore whether supplementation with high doses of vitamin D could reduce the incidence of COPD exacerbations.
Design
Randomized, single-center, double-blind, placebo-controlled trial. (ClinicalTrials.gov registration number: NCT00666367)
Setting
University Hospitals Leuven, Leuven, Belgium.
Patients
182 patients with moderate to very severe COPD and a history of recent exacerbations.
Intervention
100,000 IU of vitamin D supplementation or placebo every 4 weeks for 1 year.
Measurements
The primary outcome was time to first exacerbation. Secondary outcomes were exacerbation rate, time to first hospitalization, time to second exacerbation, FEV(1), quality of life, and death.
Results
Mean serum 25-(OH)D levels increased significantly in the vitamin D group compared with the placebo group (mean between-group difference, 30 ng/mL [95% CI, 27 to 33 ng/mL]; P < 0.001). The median time to first exacerbation did not significantly differ between the groups (hazard ratio, 1.1 [CI, 0.82 to 1.56]; P = 0.41), nor did exacerbation rates, FEV(1), hospitalization, quality of life, and death. However, a post hoc analysis in 30 participants with severe vitamin D deficiency (serum 25-[OH]D levels <10 ng/mL) at baseline showed a significant reduction in exacerbations in the vitamin D group (rate ratio, 0.57 [CI, 0.33 to 0.98]; P = 0.042).
Limitation
This was a single-center study with a small sample size.
Conclusion
High-dose vitamin D supplementation in a sample of patients with COPD did not reduce the incidence of exacerbations. In participants with severe vitamin D deficiency at baseline, supplementation may reduce exacerbations.
Primary funding source
Applied Biomedical Research Program, Agency for Innovation by Science and Technology (IWT-TBM).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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